2do5

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Current revision (16:34, 13 December 2023) (edit) (undo)
 
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==Solution structure of the SAP domain of human splicing factor 3B subunit 2==
==Solution structure of the SAP domain of human splicing factor 3B subunit 2==
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<StructureSection load='2do5' size='340' side='right'caption='[[2do5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2do5' size='340' side='right'caption='[[2do5]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2do5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DO5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2do5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DO5 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SF3B2, SAP145 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2do5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2do5 OCA], [https://pdbe.org/2do5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2do5 RCSB], [https://www.ebi.ac.uk/pdbsum/2do5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2do5 ProSAT], [https://www.topsan.org/Proteins/RSGI/2do5 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2do5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2do5 OCA], [https://pdbe.org/2do5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2do5 RCSB], [https://www.ebi.ac.uk/pdbsum/2do5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2do5 ProSAT], [https://www.topsan.org/Proteins/RSGI/2do5 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SF3B2_HUMAN SF3B2_HUMAN]] Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
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[https://www.uniprot.org/uniprot/SF3B2_HUMAN SF3B2_HUMAN] Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Muto, Y]]
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[[Category: Muto Y]]
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[[Category: Structural genomic]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M]]
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[[Category: Suzuki S]]
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[[Category: Suzuki, S]]
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[[Category: Terada T]]
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[[Category: Terada, T]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Sap domain]]
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[[Category: Unknown function]]
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Current revision

Solution structure of the SAP domain of human splicing factor 3B subunit 2

PDB ID 2do5

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