2g0l

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Current revision (16:36, 13 December 2023) (edit) (undo)
 
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==Solution Structure of Neocarzinostatin Apo-Protein with bound Flavone==
==Solution Structure of Neocarzinostatin Apo-Protein with bound Flavone==
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<StructureSection load='2g0l' size='340' side='right'caption='[[2g0l]], [[NMR_Ensembles_of_Models | 58 NMR models]]' scene=''>
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<StructureSection load='2g0l' size='340' side='right'caption='[[2g0l]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2g0l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/'streptomyces_carzinostaticus' 'streptomyces carzinostaticus']. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G0L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2g0l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G0L FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLN:2-PHENYL-4H-CHROMEN-4-ONE'>FLN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j5h|1j5h]], [[1j5i|1j5i]], [[2g0k|2g0k]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLN:2-PHENYL-4H-CHROMEN-4-ONE'>FLN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ncsA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1897 'Streptomyces carzinostaticus'])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0l OCA], [https://pdbe.org/2g0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g0l RCSB], [https://www.ebi.ac.uk/pdbsum/2g0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g0l ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0l OCA], [https://pdbe.org/2g0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g0l RCSB], [https://www.ebi.ac.uk/pdbsum/2g0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g0l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ]] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
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[https://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Streptomyces carzinostaticus]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Caddick, S]]
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[[Category: Streptomyces carzinostaticus]]
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[[Category: Muskett, F W]]
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[[Category: Caddick S]]
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[[Category: Stoneman, R G]]
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[[Category: Muskett FW]]
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[[Category: Woolfson, D N]]
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[[Category: Stoneman RG]]
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[[Category: Antibiotic]]
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[[Category: Woolfson DN]]
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[[Category: Beta sandwich]]
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[[Category: Igg fold]]
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Current revision

Solution Structure of Neocarzinostatin Apo-Protein with bound Flavone

PDB ID 2g0l

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