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5ofa

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==Crystal structure of human MORC2 (residues 1-603) with spinal muscular atrophy mutation T424R==
==Crystal structure of human MORC2 (residues 1-603) with spinal muscular atrophy mutation T424R==
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<StructureSection load='5ofa' size='340' side='right' caption='[[5ofa]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
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<StructureSection load='5ofa' size='340' side='right'caption='[[5ofa]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ofa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OFA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ofa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OFA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MORC2, KIAA0852, ZCWCC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ofa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ofa OCA], [http://pdbe.org/5ofa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ofa RCSB], [http://www.ebi.ac.uk/pdbsum/5ofa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ofa ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ofa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ofa OCA], [https://pdbe.org/5ofa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ofa RCSB], [https://www.ebi.ac.uk/pdbsum/5ofa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ofa ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/MORC2_HUMAN MORC2_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/MORC2_HUMAN MORC2_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MORC2_HUMAN MORC2_HUMAN]] Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). May act as a transcriptional repressor (PubMed:20225202). Down-regulates CA9 expression (PubMed:20110259).<ref>PMID:20110259</ref> <ref>PMID:20225202</ref> <ref>PMID:24286864</ref>
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[https://www.uniprot.org/uniprot/MORC2_HUMAN MORC2_HUMAN] Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). May act as a transcriptional repressor (PubMed:20225202). Down-regulates CA9 expression (PubMed:20110259).<ref>PMID:20110259</ref> <ref>PMID:20225202</ref> <ref>PMID:24286864</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Douse, C H]]
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[[Category: Large Structures]]
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[[Category: Liu, Y]]
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[[Category: Douse CH]]
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[[Category: Modis, Y]]
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[[Category: Liu Y]]
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[[Category: Charcot-marie-tooth disease]]
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[[Category: Modis Y]]
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[[Category: Chromatin remodeler]]
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[[Category: Coiled-coil]]
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[[Category: Cw domain]]
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[[Category: Dna binding protein]]
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[[Category: Epigenetic silencing]]
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[[Category: Ghkl atpase]]
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[[Category: Nuclear protein]]
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[[Category: Spinal muscular atrophy]]
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[[Category: Transcriptional repressor]]
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Revision as of 16:47, 13 December 2023

Crystal structure of human MORC2 (residues 1-603) with spinal muscular atrophy mutation T424R

PDB ID 5ofa

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