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5oj6

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Current revision (16:51, 13 December 2023) (edit) (undo)
 
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==Crystal structure of the chicken MDGA1 ectodomain in complex with the human neuroligin 1 (NL1(-A-B)) cholinesterase domain.==
==Crystal structure of the chicken MDGA1 ectodomain in complex with the human neuroligin 1 (NL1(-A-B)) cholinesterase domain.==
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<StructureSection load='5oj6' size='340' side='right' caption='[[5oj6]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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<StructureSection load='5oj6' size='340' side='right'caption='[[5oj6]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5oj6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OJ6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5oj6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OJ6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NLGN1, KIAA1070 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), MDGA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oj6 OCA], [http://pdbe.org/5oj6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oj6 RCSB], [http://www.ebi.ac.uk/pdbsum/5oj6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oj6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oj6 OCA], [https://pdbe.org/5oj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5oj6 RCSB], [https://www.ebi.ac.uk/pdbsum/5oj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5oj6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NLGN1_HUMAN NLGN1_HUMAN]] Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.[UniProtKB:Q99K10]
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[https://www.uniprot.org/uniprot/NLGN1_HUMAN NLGN1_HUMAN] Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.[UniProtKB:Q99K10]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5oj6" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5oj6" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Neuroligin|Neuroligin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chick]]
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[[Category: Gallus gallus]]
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Aricescu, A R]]
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[[Category: Large Structures]]
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[[Category: Clayton, A J]]
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[[Category: Aricescu AR]]
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[[Category: Elegheert, J]]
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[[Category: Clayton AJ]]
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[[Category: Cell adhesion]]
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[[Category: Elegheert J]]
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[[Category: Neuroligin-neurexin]]
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[[Category: Synapse formation]]
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[[Category: Synaptic transmission]]
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Current revision

Crystal structure of the chicken MDGA1 ectodomain in complex with the human neuroligin 1 (NL1(-A-B)) cholinesterase domain.

PDB ID 5oj6

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