5oll

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Current revision (16:53, 13 December 2023) (edit) (undo)
 
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==Crystal structure of gurmarin, a sweet taste suppressing polypeptide==
==Crystal structure of gurmarin, a sweet taste suppressing polypeptide==
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<StructureSection load='5oll' size='340' side='right' caption='[[5oll]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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<StructureSection load='5oll' size='340' side='right'caption='[[5oll]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5oll]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gymsy Gymsy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OLL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5oll]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OLL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oll OCA], [http://pdbe.org/5oll PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oll RCSB], [http://www.ebi.ac.uk/pdbsum/5oll PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oll ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5oll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oll OCA], [https://pdbe.org/5oll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5oll RCSB], [https://www.ebi.ac.uk/pdbsum/5oll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5oll ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GUR_GYMSY GUR_GYMSY]] Suppresses strongly the sweet taste responses in the rat with high specificity to sucrose, glucose, glycine, and saccharin. This effect is reversible, but complete recovery of the suppressed responses required at least 3h. Gurmarin showed no effect or only a very weak effect on the sweet taste sensation in humans.
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[https://www.uniprot.org/uniprot/GUR_GYMSY GUR_GYMSY] Suppresses strongly the sweet taste responses in the rat with high specificity to sucrose, glucose, glycine, and saccharin. This effect is reversible, but complete recovery of the suppressed responses required at least 3h. Gurmarin showed no effect or only a very weak effect on the sweet taste sensation in humans.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Gymsy]]
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[[Category: Gymnema sylvestre]]
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[[Category: Briand, L]]
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[[Category: Large Structures]]
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[[Category: Legrand, P]]
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[[Category: Briand L]]
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[[Category: Neiers, F]]
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[[Category: Legrand P]]
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[[Category: Roblin, P]]
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[[Category: Neiers F]]
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[[Category: Sigoillot, M]]
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[[Category: Roblin P]]
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[[Category: Gpcr]]
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[[Category: Sigoillot M]]
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[[Category: Gurmarin]]
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[[Category: Inhibitor]]
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[[Category: Knottin]]
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[[Category: Plant protein]]
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[[Category: Sweet]]
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[[Category: Taste]]
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Current revision

Crystal structure of gurmarin, a sweet taste suppressing polypeptide

PDB ID 5oll

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