1p0z

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[[Image:1p0z.gif|left|200px]]
[[Image:1p0z.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1p0z |SIZE=350|CAPTION= <scene name='initialview01'>1p0z</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1p0z", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MO7:HEPTAMOLYBDATE'>MO7</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OMO:MO(VI)(=O)(OH)2+CLUSTER'>OMO</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CITA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 Klebsiella pneumoniae])
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-->
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|DOMAIN=
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{{STRUCTURE_1p0z| PDB=1p0z | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p0z OCA], [http://www.ebi.ac.uk/pdbsum/1p0z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p0z RCSB]</span>
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}}
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'''Sensor Kinase CitA binding domain'''
'''Sensor Kinase CitA binding domain'''
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[[Category: Madden, D R.]]
[[Category: Madden, D R.]]
[[Category: Reinelt, S.]]
[[Category: Reinelt, S.]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:32:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:53:15 2008''
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Revision as of 01:32, 3 May 2008

Image:1p0z.gif

Template:STRUCTURE 1p0z

Sensor Kinase CitA binding domain


Overview

The integral membrane sensor kinase CitA of Klebsiella pneumoniae is part of a two-component signal transduction system that regulates the transport and metabolism of citrate in response to its environmental concentration. Two-component systems are widely used by bacteria for such adaptive processes, but the stereochemistry of periplasmic ligand binding and the mechanism of signal transduction across the membrane remain poorly understood. The crystal structure of the CitAP periplasmic sensor domain in complex with citrate reveals a PAS fold, a versatile ligand-binding structural motif that has not previously been observed outside the cytoplasm or implicated in the transduction of conformational signals across the membrane. Citrate is bound in a pocket that is shared among many PAS domains but that shows structural variation according to the nature of the bound ligand. In CitAP, some of the citrate contact residues are located in the final strand of the central beta-sheet, which is connected to the C-terminal transmembrane helix. These secondary structure elements thus provide a potential conformational link between the periplasmic ligand binding site and the cytoplasmic signaling domains of the receptor.

About this Structure

1P0Z is a Single protein structure of sequence from Klebsiella pneumoniae. Full crystallographic information is available from OCA.

Reference

The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain., Reinelt S, Hofmann E, Gerharz T, Bott M, Madden DR, J Biol Chem. 2003 Oct 3;278(40):39189-96. Epub 2003 Jul 16. PMID:12867417 Page seeded by OCA on Sat May 3 04:32:51 2008

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