1p1z

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[[Image:1p1z.gif|left|200px]]
[[Image:1p1z.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1p1z |SIZE=350|CAPTION= <scene name='initialview01'>1p1z</scene>, resolution 3.26&Aring;
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The line below this paragraph, containing "STRUCTURE_1p1z", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= H2-K ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), KLRA3 OR LY49C OR LY-49C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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{{STRUCTURE_1p1z| PDB=1p1z | SCENE= }}
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|RELATEDENTRY=[[1qo3|1QO3]], [[1ja3|1JA3]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p1z OCA], [http://www.ebi.ac.uk/pdbsum/1p1z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p1z RCSB]</span>
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}}
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'''X-RAY CRYSTAL STRUCTURE OF THE LECTIN-LIKE NATURAL KILLER CELL RECEPTOR LY-49C BOUND TO ITS MHC CLASS I LIGAND H-2Kb'''
'''X-RAY CRYSTAL STRUCTURE OF THE LECTIN-LIKE NATURAL KILLER CELL RECEPTOR LY-49C BOUND TO ITS MHC CLASS I LIGAND H-2Kb'''
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[[Category: Natarajan, K.]]
[[Category: Natarajan, K.]]
[[Category: Rangjin, G.]]
[[Category: Rangjin, G.]]
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[[Category: antigenic peptide]]
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[[Category: Antigenic peptide]]
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[[Category: kb]]
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[[Category: Kb]]
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[[Category: ly49]]
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[[Category: Ly49]]
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[[Category: mhc]]
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[[Category: Mhc]]
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[[Category: nk]]
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[[Category: Nk]]
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[[Category: ova]]
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[[Category: Ova]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:34:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:53:38 2008''
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Revision as of 01:34, 3 May 2008

Image:1p1z.gif

Template:STRUCTURE 1p1z

X-RAY CRYSTAL STRUCTURE OF THE LECTIN-LIKE NATURAL KILLER CELL RECEPTOR LY-49C BOUND TO ITS MHC CLASS I LIGAND H-2Kb


Overview

The Ly49 family of natural killer (NK) receptors regulates NK cell function by sensing major histocompatibility complex (MHC) class I. Ly49 receptors show complex patterns of MHC class I cross-reactivity and, in certain cases, peptide selectivity. To investigate whether specificity differences result from topological differences in MHC class I engagement, we determined the structure of the peptide-selective receptor Ly49C in complex with H-2K(b). The Ly49C homodimer binds two MHC class I molecules in symmetrical way, a mode distinct from that of Ly49A, which binds MHC class I asymmetrically. Ly49C does not directly contact the MHC-bound peptide. In addition, MHC crosslinking by Ly49C was demonstrated in solution. We propose a dynamic model for Ly49-MHC class I interactions involving conformational changes in the receptor, whereby variations in Ly49 dimerization mediate different MHC-binding modes.

About this Structure

1P1Z is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b)., Dam J, Guan R, Natarajan K, Dimasi N, Chlewicki LK, Kranz DM, Schuck P, Margulies DH, Mariuzza RA, Nat Immunol. 2003 Dec;4(12):1213-22. Epub 2003 Nov 2. PMID:14595439 Page seeded by OCA on Sat May 3 04:34:46 2008

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OCA

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