8orv
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of monkeypox virus poxin in complex with the STING agonist MD1203== | |
| - | + | <StructureSection load='8orv' size='340' side='right'caption='[[8orv]], [[Resolution|resolution]] 1.65Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8orv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Monkeypox_virus Monkeypox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ORV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ORV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VZ6:9-[(1~{S},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one'>VZ6</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8orv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8orv OCA], [https://pdbe.org/8orv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8orv RCSB], [https://www.ebi.ac.uk/pdbsum/8orv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8orv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/POXIN_MONPV POXIN_MONPV] Nuclease that is responsible for viral evasion of host cGAS-STING innate immunity. Cleaves 2',3'-cGAMP which is produced by host cGAS following recognition of cytosolic DNA and blocks the subsequent 2',3'-cGAMP-mediated activation of TMEM173/STING, which normally spreads to adjacent cells and activates the interferon and NF-kappa-B immune responses. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Monkeypox virus]] | ||
| + | [[Category: Boura E]] | ||
| + | [[Category: Duchoslav V]] | ||
| + | [[Category: Klima M]] | ||
Current revision
Crystal structure of monkeypox virus poxin in complex with the STING agonist MD1203
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