8ter

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Current revision (10:05, 20 December 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8ter is ON HOLD until Paper Publication
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==Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fiber==
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<StructureSection load='8ter' size='340' side='right'caption='[[8ter]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
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Authors: Rosenberg, G.M., Sawaya, M.R., Boyer, D.R., Ge, P., Abskharon, R., Eisenberg, D.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ter]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Purpureocillium_lilacinum Purpureocillium lilacinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TER FirstGlance]. <br>
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Description: Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fiber
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ter FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ter OCA], [https://pdbe.org/8ter PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ter RCSB], [https://www.ebi.ac.uk/pdbsum/8ter PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ter ProSAT]</span></td></tr>
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[[Category: Sawaya, M.R]]
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</table>
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[[Category: Rosenberg, G.M]]
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== Disease ==
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[[Category: Eisenberg, D.S]]
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[https://www.uniprot.org/uniprot/TFG_HUMAN TFG_HUMAN] Autosomal recessive spastic paraplegia type 57;Extraskeletal myxoid chondrosarcoma;Autosomal dominant Charcot-Marie-Tooth disease type 2 due to TFG mutation;Hereditary motor and sensory neuropathy, Okinawa type;Differentiated thyroid carcinoma. A chromosomal aberration involving TFG is found in papillary thyroid carcinomas (PTCs). Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.<ref>PMID:7565764</ref> The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
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[[Category: Ge, P]]
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== Function ==
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[[Category: Boyer, D.R]]
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[https://www.uniprot.org/uniprot/TFG_HUMAN TFG_HUMAN] Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858).<ref>PMID:21478858</ref> <ref>PMID:23479643</ref> <ref>PMID:27813252</ref> [https://www.uniprot.org/uniprot/A0A2U3DNX3_PURLI A0A2U3DNX3_PURLI]
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[[Category: Abskharon, R]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Purpureocillium lilacinum]]
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[[Category: Abskharon R]]
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[[Category: Boyer DR]]
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[[Category: Eisenberg DS]]
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[[Category: Ge P]]
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[[Category: Rosenberg GM]]
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[[Category: Sawaya MR]]

Current revision

Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fiber

PDB ID 8ter

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