2wql

From Proteopedia

(Difference between revisions)

Current revision

CRYSTAL STRUCTURE OF THE MAJOR CARROT ALLERGEN DAU C 1

Structural highlights

2wql is a 4 chain structure with sequence from Daucus carota. This structure supersedes the now removed PDB entry 2vjg. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.7Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DAU1_DAUCA

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Dau c 1 is a major allergen of carrot (Daucus carota) which displays IgE cross-reactivity with the homologous major birch-pollen allergen Bet v 1. The crystal structure of Dau c 1 has been determined to a resolution of 2.7 A, revealing tight dimers. The structure of Dau c 1 is similar to those of the major allergens from celery, Api g 1, and birch pollen, Bet v 1. Electron density has been observed in the hydrophobic cavity of each monomer and has been modelled with polyethylene glycol oligomers of varying length. Comparison of the surface topology and physicochemical properties of Dau c 1 and Bet v 1 revealed that they may have some, but not all, epitopes in common. This is in agreement with the observation that the majority of carrot-allergic patients have Bet v 1 cross-reactive IgE antibodies, whereas others have Dau c 1-specific IgE antibodies which do not recognize Bet v 1.

Structure of the major carrot allergen Dau c 1.,Markovic-Housley Z, Basle A, Padavattan S, Maderegger B, Schirmer T, Hoffmann-Sommergruber K Acta Crystallogr D Biol Crystallogr. 2009 Nov;65(Pt 11):1206-12. Epub 2009, Oct 22. PMID:19923716^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Markovic-Housley Z, Basle A, Padavattan S, Maderegger B, Schirmer T, Hoffmann-Sommergruber K. Structure of the major carrot allergen Dau c 1. Acta Crystallogr D Biol Crystallogr. 2009 Nov;65(Pt 11):1206-12. Epub 2009, Oct 22. PMID:19923716 doi:10.1107/S0907444909034854

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wql"

@@ Line 3: / Line 3: @@
 <StructureSection load='2wql' size='340' side='right'caption='[[2wql]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2wql]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Dauca Dauca]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vjg 2vjg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQL FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2wql]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Daucus_carota Daucus carota]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vjg 2vjg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQL FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wql OCA], [https://pdbe.org/2wql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wql RCSB], [https://www.ebi.ac.uk/pdbsum/2wql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wql ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/DAU1_DAUCA DAU1_DAUCA]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 30: / Line 33: @@
 __TOC__
 </StructureSection>
-[[Category: Dauca]]
+[[Category: Daucus carota]]
 [[Category: Large Structures]]
-[[Category: Basle, A]]
+[[Category: Basle A]]
-[[Category: Hoffmann-Sommergruber, K]]
+[[Category: Hoffmann-Sommergruber K]]
-[[Category: Markovic-Housley, Z]]
+[[Category: Markovic-Housley Z]]
-[[Category: Padavattan, S]]
+[[Category: Padavattan S]]
-[[Category: Schirmer, T]]
+[[Category: Schirmer T]]
-[[Category: Allergen]]
-[[Category: Pathogenesis-related protein]]
-[[Category: Plant defense]]

2wql

From Proteopedia

Current revision

CRYSTAL STRUCTURE OF THE MAJOR CARROT ALLERGEN DAU C 1

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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