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2wy6

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Current revision (10:19, 20 December 2023) (edit) (undo)
 
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<StructureSection load='2wy6' size='340' side='right'caption='[[2wy6]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='2wy6' size='340' side='right'caption='[[2wy6]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wy6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus perfringens" veillon and zuber 1898]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WY6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wy6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WY6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qm6|1qm6]], [[2wxt|2wxt]], [[1qmd|1qmd]], [[2wxu|2wxu]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_C Phospholipase C], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.3 3.1.4.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wy6 OCA], [https://pdbe.org/2wy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wy6 RCSB], [https://www.ebi.ac.uk/pdbsum/2wy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wy6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wy6 OCA], [https://pdbe.org/2wy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wy6 RCSB], [https://www.ebi.ac.uk/pdbsum/2wy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wy6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PHLC_CLOP1 PHLC_CLOP1]] Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Constitutes an essential virulence factor in gas gangrene. Binds to eukaryotic membranes where it hydrolyzes both phosphatidylcholine and sphingomyelin. The diacylglycerol produced can activate both the arachidonic acid pathway, leading to modulation of the inflammatory response cascade and thrombosis, and protein kinase C, leading to activation of eukaryotic phospholipases and further membrane damage. Acts on human and mouse erythrocytes, but not on rabbit or horse erythrocytes.
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[https://www.uniprot.org/uniprot/PHLC_CLOP1 PHLC_CLOP1] Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Constitutes an essential virulence factor in gas gangrene. Binds to eukaryotic membranes where it hydrolyzes both phosphatidylcholine and sphingomyelin. The diacylglycerol produced can activate both the arachidonic acid pathway, leading to modulation of the inflammatory response cascade and thrombosis, and protein kinase C, leading to activation of eukaryotic phospholipases and further membrane damage. Acts on human and mouse erythrocytes, but not on rabbit or horse erythrocytes.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus perfringens veillon and zuber 1898]]
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[[Category: Clostridium perfringens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Phospholipase C]]
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[[Category: Basak AK]]
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[[Category: Basak, A K]]
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[[Category: Naylor CE]]
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[[Category: Naylor, C E]]
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[[Category: Vachieri SG]]
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[[Category: Vachieri, S G]]
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[[Category: C2 domain]]
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[[Category: Cytolysis]]
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[[Category: Gangrene determinant]]
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[[Category: Hemolysis]]
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[[Category: Hydrolase]]
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[[Category: Membrane binding]]
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[[Category: Virulence]]
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Current revision

Clostridium perfringens alpha-toxin strain NCTC8237 mutant T74I

PDB ID 2wy6

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