2x4d
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='2x4d' size='340' side='right'caption='[[2x4d]], [[Resolution|resolution]] 1.92Å' scene=''> | <StructureSection load='2x4d' size='340' side='right'caption='[[2x4d]], [[Resolution|resolution]] 1.92Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2x4d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2x4d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X4D FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4d OCA], [https://pdbe.org/2x4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4d RCSB], [https://www.ebi.ac.uk/pdbsum/2x4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4d ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4d OCA], [https://pdbe.org/2x4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4d RCSB], [https://www.ebi.ac.uk/pdbsum/2x4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4d ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LHPP_HUMAN LHPP_HUMAN] Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 19: | Line 22: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Allerston | + | [[Category: Allerston C]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | + | [[Category: Edwards A]] | |
| - | [[Category: Edwards | + | [[Category: Gileadi C]] |
| - | [[Category: Gileadi | + | [[Category: Guo K]] |
| - | [[Category: Guo | + | [[Category: Kavanagh KL]] |
| - | [[Category: Kavanagh | + | [[Category: Muniz JRC]] |
| - | [[Category: Muniz | + | [[Category: Oppermann U]] |
| - | [[Category: Oppermann | + | [[Category: Savitsky P]] |
| - | [[Category: Savitsky | + | [[Category: Vollmar M]] |
| - | [[Category: Vollmar | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Yue W]] |
| - | [[Category: Yue | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
Current revision
Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase LHPP
| |||||||||||
Categories: Homo sapiens | Large Structures | Allerston C | Arrowsmith CH | Bountra C | Edwards A | Gileadi C | Guo K | Kavanagh KL | Muniz JRC | Oppermann U | Savitsky P | Vollmar M | Weigelt J | Yue W | Von Delft F
