2xec

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Current revision (10:29, 20 December 2023) (edit) (undo)
 
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<StructureSection load='2xec' size='340' side='right'caption='[[2xec]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2xec' size='340' side='right'caption='[[2xec]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xec]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nocfa Nocfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XEC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xec]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nocardia_farcinica_IFM_10152 Nocardia farcinica IFM 10152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XEC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Maleate_isomerase Maleate isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.1 5.2.1.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xec OCA], [https://pdbe.org/2xec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xec RCSB], [https://www.ebi.ac.uk/pdbsum/2xec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xec ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xec OCA], [https://pdbe.org/2xec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xec RCSB], [https://www.ebi.ac.uk/pdbsum/2xec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xec ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAIA_NOCFA MAIA_NOCFA] Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate. Shows a strict specificity for maleate, with no activity detected toward structurally related substrates including citraconate, mesaconate, dimethylmaleate, and maleamide.<ref>PMID:20677745</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Maleate isomerase]]
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[[Category: Nocardia farcinica IFM 10152]]
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[[Category: Nocfa]]
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[[Category: Baudendistel N]]
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[[Category: Baudendistel, N]]
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[[Category: Bruce NC]]
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[[Category: Bruce, N C]]
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[[Category: Fisch F]]
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[[Category: Fisch, F]]
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[[Category: Grogan G]]
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[[Category: Grogan, G]]
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[[Category: Hart S]]
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[[Category: Hart, S]]
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[[Category: Hauer B]]
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[[Category: Hauer, B]]
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[[Category: Martinez-Fleites C]]
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[[Category: Martinez-Fleites, C]]
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[[Category: Turkenburg JP]]
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[[Category: Turkenburg, J P]]
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[[Category: Isomerase]]
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Current revision

Nocardia farcinica maleate cis-trans isomerase bound to TRIS

PDB ID 2xec

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