1p3q
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1p3q.gif|left|200px]] | [[Image:1p3q.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1p3q", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1p3q| PDB=1p3q | SCENE= }} | |
| - | | | + | |
| - | + | ||
| - | }} | + | |
'''Mechanism of Ubiquitin Recognition by the CUE Domain of VPS9''' | '''Mechanism of Ubiquitin Recognition by the CUE Domain of VPS9''' | ||
| Line 33: | Line 30: | ||
[[Category: Misra, S.]] | [[Category: Misra, S.]] | ||
[[Category: Prag, G.]] | [[Category: Prag, G.]] | ||
| - | [[Category: | + | [[Category: Mono-ubiquitination]] |
| - | [[Category: | + | [[Category: Post translational modification]] |
| - | [[Category: | + | [[Category: Trafficking]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:38:50 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 01:38, 3 May 2008
Mechanism of Ubiquitin Recognition by the CUE Domain of VPS9
Overview
Coupling of ubiquitin conjugation to ER degradation (CUE) domains are approximately 50 amino acid monoubiquitin binding motifs found in proteins of trafficking and ubiquitination pathways. The 2.3 A structure of the Vps9p-CUE domain is a dimeric domain-swapped variant of the ubiquitin binding UBA domain. The 1.7 A structure of the CUE:ubiquitin complex shows that one CUE dimer binds one ubiquitin molecule. The bound CUE dimer is kinked relative to the unbound CUE dimer and wraps around ubiquitin. The CUE monomer contains two ubiquitin binding surfaces on opposite faces of the molecule that cannot bind simultaneously to a single ubiquitin molecule. Dimerization of the CUE domain allows both surfaces to contact a single ubiquitin molecule, providing a mechanism for high-affinity binding to monoubiquitin.
About this Structure
1P3Q is a Protein complex structure of sequences from Bos taurus and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Mechanism of ubiquitin recognition by the CUE domain of Vps9p., Prag G, Misra S, Jones EA, Ghirlando R, Davies BA, Horazdovsky BF, Hurley JH, Cell. 2003 May 30;113(5):609-20. PMID:12787502 Page seeded by OCA on Sat May 3 04:38:50 2008
