2xo3
From Proteopedia
(Difference between revisions)
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<StructureSection load='2xo3' size='340' side='right'caption='[[2xo3]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2xo3' size='340' side='right'caption='[[2xo3]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2xo3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2xo3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XO3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XO3 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IZO:(2S)-2-AMINOHEX-5-YNOIC+ACID'>IZO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xo3 OCA], [https://pdbe.org/2xo3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xo3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xo3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xo3 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xo3 OCA], [https://pdbe.org/2xo3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xo3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xo3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xo3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/ANXA5_HUMAN ANXA5_HUMAN] Defects in ANXA5 are associated with susceptibility to pregnancy loss, recurrent, type 3 (RPRGL3) [MIM:[https://omim.org/entry/614391 614391]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.<ref>PMID:17339269</ref> | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/ANXA5_HUMAN ANXA5_HUMAN] This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. | |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Budisa | + | [[Category: Budisa N]] |
| - | [[Category: Debela | + | [[Category: Debela M]] |
| - | [[Category: Goettig | + | [[Category: Goettig P]] |
| - | [[Category: Merkel | + | [[Category: Merkel L]] |
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Current revision
Human Annexin V with incorporated Methionine analogue Homopropargylglycine
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