1p49

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[[Image:1p49.jpg|left|200px]]
[[Image:1p49.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1p49 |SIZE=350|CAPTION= <scene name='initialview01'>1p49</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1p49", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ALS:2-AMINO-3-OXO-4-SULFO-BUTYRIC+ACID'>ALS</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Steryl-sulfatase Steryl-sulfatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.6.2 3.1.6.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1p49| PDB=1p49 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p49 OCA], [http://www.ebi.ac.uk/pdbsum/1p49 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p49 RCSB]</span>
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}}
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'''Structure of Human Placental Estrone/DHEA Sulfatase'''
'''Structure of Human Placental Estrone/DHEA Sulfatase'''
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[[Category: Osawa, Y.]]
[[Category: Osawa, Y.]]
[[Category: Pangborn, W.]]
[[Category: Pangborn, W.]]
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[[Category: dehydroepiandrosterone sulfate]]
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[[Category: Dehydroepiandrosterone sulfate]]
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[[Category: endoplasmic reticulum membrane-bound]]
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[[Category: Endoplasmic reticulum membrane-bound]]
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[[Category: estrone sulfate]]
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[[Category: Estrone sulfate]]
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[[Category: human placental enzyme]]
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[[Category: Human placental enzyme]]
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[[Category: steroid biosynthesis]]
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[[Category: Steroid biosynthesis]]
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[[Category: steroid sulfatase]]
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[[Category: Steroid sulfatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:39:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:54:37 2008''
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Revision as of 01:39, 3 May 2008

Image:1p49.jpg

Template:STRUCTURE 1p49

Structure of Human Placental Estrone/DHEA Sulfatase


Overview

Estrone sulfatase (ES; 562 amino acids), one of the key enzymes responsible for maintaining high levels of estrogens in breast tumor cells, is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES, purified from the microsomal fraction of human placentas, has been determined at 2.60-A resolution by x-ray crystallography. This structure shows a domain consisting of two antiparallel alpha-helices that protrude from the roughly spherical molecule, thereby giving the molecule a "mushroom-like" shape. These highly hydrophobic helices, each about 40 A long, are capable of traversing the membrane, thus presumably anchoring the functional domain on the membrane surface facing the ER lumen. The location of the transmembrane domain is such that the opening to the active site, buried deep in a cavity of the "gill" of the "mushroom," rests near the membrane surface, thereby suggesting a role of the lipid bilayer in catalysis. This simple architecture could be a prototype utilized by the ER membrane in dictating the form and the function of ER-resident enzymes.

About this Structure

1P49 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human estrone sulfatase suggests functional roles of membrane association., Hernandez-Guzman FG, Higashiyama T, Pangborn W, Osawa Y, Ghosh D, J Biol Chem. 2003 Jun 20;278(25):22989-97. Epub 2003 Mar 25. PMID:12657638 Page seeded by OCA on Sat May 3 04:39:52 2008

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