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1qnd
From Proteopedia
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(New page: 200px<br /> <applet load="1qnd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qnd" /> '''STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURE...)
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Revision as of 16:48, 12 November 2007
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STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES
Overview
The determination of the NMR structure of the sterol carrier protein-2, (SCP2), analysis of backbone (15)N spin relaxation parameters and NMR, studies of nitroxide spin-labeled substrate binding are presented as a new, basis for investigations of the mode of action of SCP2. The SCP2 fold is, formed by a five-stranded beta-sheet and four alpha-helices. Fatty acid, binding to a hydrophobic surface area formed by amino acid residues of the, first and third helices, and the beta-sheet, which are all located in the, polypeptide segment 8-102, was identified with the use of the spin-labeled, substrate 16-doxylstearic acid. In the free protein, the lipid-binding, site is covered by the C-terminal segment 105-123, suggesting that this, polypeptide segment, which carries the peroxisomal targeting signal, (PTS1), might be involved in the regulation of ligand binding.
About this Structure
1QND is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
NMR structure of the sterol carrier protein-2: implications for the biological role., Garcia FL, Szyperski T, Dyer JH, Choinowski T, Seedorf U, Hauser H, Wuthrich K, J Mol Biol. 2000 Jan 21;295(3):595-603. PMID:10623549
Page seeded by OCA on Mon Nov 12 18:54:56 2007
