2ye5

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Current revision (10:50, 20 December 2023) (edit) (undo)
 
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<StructureSection load='2ye5' size='340' side='right'caption='[[2ye5]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
<StructureSection load='2ye5' size='340' side='right'caption='[[2ye5]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ye5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YE5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ye5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YE5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2A7:5-METHOXY-BENZENE-1,3-DIOL'>2A7</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yes|1yes]], [[1uy9|1uy9]], [[2cdd|2cdd]], [[1byq|1byq]], [[2bsm|2bsm]], [[1osf|1osf]], [[2wi3|2wi3]], [[1uy8|1uy8]], [[2bug|2bug]], [[2wi4|2wi4]], [[2uwd|2uwd]], [[2xhx|2xhx]], [[2wi7|2wi7]], [[2bt0|2bt0]], [[1yer|1yer]], [[2xdu|2xdu]], [[1uyg|1uyg]], [[2ccu|2ccu]], [[2bz5|2bz5]], [[2xds|2xds]], [[2xdx|2xdx]], [[2ccs|2ccs]], [[2xk2|2xk2]], [[2xjj|2xjj]], [[1yc3|1yc3]], [[1uyi|1uyi]], [[1uyf|1uyf]], [[1uyd|1uyd]], [[2byi|2byi]], [[2wi2|2wi2]], [[2xdl|2xdl]], [[2vci|2vci]], [[1uy6|1uy6]], [[2wi1|2wi1]], [[2vcj|2vcj]], [[1yc4|1yc4]], [[2xjx|2xjx]], [[2c2l|2c2l]], [[2fwz|2fwz]], [[2xdk|2xdk]], [[2xjg|2xjg]], [[1uyk|1uyk]], [[1uyh|1uyh]], [[2cct|2cct]], [[2fwy|2fwy]], [[1uye|1uye]], [[1uyl|1uyl]], [[2wi6|2wi6]], [[2xab|2xab]], [[1yc1|1yc1]], [[1uy7|1uy7]], [[1uyc|1uyc]], [[2xht|2xht]], [[2xhr|2xhr]], [[1yet|1yet]], [[2jjc|2jjc]], [[2byh|2byh]], [[2wi5|2wi5]], [[2yee|2yee]], [[2ye2|2ye2]], [[2ye9|2ye9]], [[2yeb|2yeb]], [[2ye7|2ye7]], [[2ye4|2ye4]], [[2yej|2yej]], [[2yec|2yec]], [[2yea|2yea]], [[2yeh|2yeh]], [[2ye6|2ye6]], [[2yed|2yed]], [[2yei|2yei]], [[2yeg|2yeg]], [[2yef|2yef]], [[2ye8|2ye8]], [[2ye3|2ye3]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2A7:5-METHOXY-BENZENE-1,3-DIOL'>2A7</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ye5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ye5 OCA], [https://pdbe.org/2ye5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ye5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ye5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ye5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ye5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ye5 OCA], [https://pdbe.org/2ye5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ye5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ye5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ye5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Baker, L M]]
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[[Category: Baker LM]]
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[[Category: Hubbard, R E]]
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[[Category: Hubbard RE]]
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[[Category: Roughley, S D]]
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[[Category: Roughley SD]]
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[[Category: Atp-binding]]
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[[Category: Atpase]]
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[[Category: Chaperone]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Phosphorylation]]
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[[Category: Pu3]]
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[[Category: Stress response]]
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Current revision

HSP90 inhibitors and drugs from fragment and virtual screening

PDB ID 2ye5

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