2yef

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:51, 20 December 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='2yef' size='340' side='right'caption='[[2yef]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='2yef' size='340' side='right'caption='[[2yef]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2yef]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YEF FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2yef]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YEF FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cdd|2cdd]], [[1yes|1yes]], [[1uy9|1uy9]], [[1byq|1byq]], [[2bsm|2bsm]], [[1osf|1osf]], [[2wi3|2wi3]], [[1uy8|1uy8]], [[2bug|2bug]], [[2wi4|2wi4]], [[2uwd|2uwd]], [[2xhx|2xhx]], [[2wi7|2wi7]], [[2bt0|2bt0]], [[1yer|1yer]], [[2xdu|2xdu]], [[1uyg|1uyg]], [[2ccu|2ccu]], [[2bz5|2bz5]], [[2xds|2xds]], [[2xdx|2xdx]], [[2ccs|2ccs]], [[2xk2|2xk2]], [[1yc3|1yc3]], [[1uyi|1uyi]], [[2xjj|2xjj]], [[1uyf|1uyf]], [[1uyd|1uyd]], [[2byi|2byi]], [[2xdl|2xdl]], [[2wi2|2wi2]], [[2vci|2vci]], [[1uy6|1uy6]], [[2wi1|2wi1]], [[2vcj|2vcj]], [[1yc4|1yc4]], [[2xjx|2xjx]], [[2c2l|2c2l]], [[2fwz|2fwz]], [[2xdk|2xdk]], [[1uyk|1uyk]], [[2xjg|2xjg]], [[1uyh|1uyh]], [[2cct|2cct]], [[2fwy|2fwy]], [[1uye|1uye]], [[1uyl|1uyl]], [[2xab|2xab]], [[2wi6|2wi6]], [[1yc1|1yc1]], [[2xhr|2xhr]], [[1uy7|1uy7]], [[1uyc|1uyc]], [[2xht|2xht]], [[1yet|1yet]], [[2jjc|2jjc]], [[2byh|2byh]], [[2wi5|2wi5]], [[2yee|2yee]], [[2ye2|2ye2]], [[2ye9|2ye9]], [[2yeb|2yeb]], [[2ye7|2ye7]], [[2ye4|2ye4]], [[2yej|2yej]], [[2yec|2yec]], [[2ye5|2ye5]], [[2yea|2yea]], [[2yeh|2yeh]], [[2ye6|2ye6]], [[2yed|2yed]], [[2yei|2yei]], [[2yeg|2yeg]], [[2ye8|2ye8]], [[2ye3|2ye3]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yef OCA], [https://pdbe.org/2yef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yef RCSB], [https://www.ebi.ac.uk/pdbsum/2yef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yef ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yef OCA], [https://pdbe.org/2yef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yef RCSB], [https://www.ebi.ac.uk/pdbsum/2yef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yef ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
+
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
==See Also==
==See Also==
Line 17: Line 17:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Baker, L M]]
+
[[Category: Baker LM]]
-
[[Category: Hubbard, R E]]
+
[[Category: Hubbard RE]]
-
[[Category: Roughley, S D]]
+
[[Category: Roughley SD]]
-
[[Category: Atp-binding]]
+
-
[[Category: Atpase]]
+
-
[[Category: Chaperone]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Phosphorylation]]
+
-
[[Category: Pu3]]
+
-
[[Category: Stress response]]
+

Current revision

HSP90 inhibitors and drugs from fragment and virtual screening

PDB ID 2yef

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2yef"
Personal tools