2yof

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Current revision (10:57, 20 December 2023) (edit) (undo)
 
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<StructureSection load='2yof' size='340' side='right'caption='[[2yof]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
<StructureSection load='2yof' size='340' side='right'caption='[[2yof]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yof]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YOF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2yof]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YOF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=74W:1-[4-CHLORANYL-3-(TRIFLUOROMETHYL)PHENYL]-3-[[(2R,3S)-5-[5-METHYL-2,4-BIS(OXIDANYLIDENE)PYRIMIDIN-1-YL]-3-OXIDANYL-OXOLAN-2-YL]METHYL]THIOUREA'>74W</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wwf|2wwf]], [[2wwg|2wwg]], [[2wwh|2wwh]], [[2wwi|2wwi]], [[2yog|2yog]], [[2yoh|2yoh]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=74W:1-[4-CHLORANYL-3-(TRIFLUOROMETHYL)PHENYL]-3-[[(2R,3S)-5-[5-METHYL-2,4-BIS(OXIDANYLIDENE)PYRIMIDIN-1-YL]-3-OXIDANYL-OXOLAN-2-YL]METHYL]THIOUREA'>74W</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yof OCA], [https://pdbe.org/2yof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yof RCSB], [https://www.ebi.ac.uk/pdbsum/2yof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yof ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yof OCA], [https://pdbe.org/2yof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yof RCSB], [https://www.ebi.ac.uk/pdbsum/2yof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yof ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KTHY_PLAF7 KTHY_PLAF7] Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP (PubMed:18477629, PubMed:19126267, PubMed:31934749, PubMed:20353400). Can also phosphorylate dGMP and to a lesser extent GMP, dUMP and dIMP (PubMed:18477629, PubMed:19126267, PubMed:31934749, PubMed:20353400). Can use either ATP or dATP as phosphate donors in presence of Mg(2+) (PubMed:18477629).<ref>PMID:18477629</ref> <ref>PMID:19126267</ref> <ref>PMID:20353400</ref> <ref>PMID:31934749</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Plaf7]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: DTMP kinase]]
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[[Category: Brannigan JA]]
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[[Category: Brannigan, J A]]
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[[Category: Carrero-Lerida J]]
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[[Category: Carrero-Lerida, J]]
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[[Category: Gilbert IH]]
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[[Category: Gilbert, I H]]
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[[Category: Gonzalez-Pacanowska D]]
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[[Category: Gonzalez-Pacanowska, D]]
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[[Category: Huaqing C]]
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[[Category: Huaqing, C]]
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[[Category: Read KD]]
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[[Category: Read, K D]]
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[[Category: Ruiz-Perez LM]]
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[[Category: Ruiz-Perez, L M]]
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[[Category: Silva APG]]
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[[Category: Silva, A P.G]]
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[[Category: Whittingham JL]]
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[[Category: Whittingham, J L]]
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[[Category: Wilson KS]]
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[[Category: Wilson, K S]]
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[[Category: Malaria]]
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[[Category: Transferase]]
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Current revision

Plasmodium falciparum thymidylate kinase in complex with a (thio)urea- beta-deoxythymidine inhibitor

PDB ID 2yof

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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