1p4l
From Proteopedia
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'''Crystal structure of NK receptor Ly49C mutant with its MHC class I ligand H-2Kb''' | '''Crystal structure of NK receptor Ly49C mutant with its MHC class I ligand H-2Kb''' | ||
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[[Category: Mariuzza, R A.]] | [[Category: Mariuzza, R A.]] | ||
[[Category: Natarajan, K.]] | [[Category: Natarajan, K.]] | ||
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| - | [[Category: | + | [[Category: Crystal structure]] |
| - | [[Category: | + | [[Category: Mhc class i]] |
| - | [[Category: | + | [[Category: Natural killer receptor]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:40:49 2008'' | |
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Revision as of 01:40, 3 May 2008
Crystal structure of NK receptor Ly49C mutant with its MHC class I ligand H-2Kb
Overview
The Ly49 family of natural killer (NK) receptors regulates NK cell function by sensing major histocompatibility complex (MHC) class I. Ly49 receptors show complex patterns of MHC class I cross-reactivity and, in certain cases, peptide selectivity. To investigate whether specificity differences result from topological differences in MHC class I engagement, we determined the structure of the peptide-selective receptor Ly49C in complex with H-2K(b). The Ly49C homodimer binds two MHC class I molecules in symmetrical way, a mode distinct from that of Ly49A, which binds MHC class I asymmetrically. Ly49C does not directly contact the MHC-bound peptide. In addition, MHC crosslinking by Ly49C was demonstrated in solution. We propose a dynamic model for Ly49-MHC class I interactions involving conformational changes in the receptor, whereby variations in Ly49 dimerization mediate different MHC-binding modes.
About this Structure
1P4L is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b)., Dam J, Guan R, Natarajan K, Dimasi N, Chlewicki LK, Kranz DM, Schuck P, Margulies DH, Mariuzza RA, Nat Immunol. 2003 Dec;4(12):1213-22. Epub 2003 Nov 2. PMID:14595439 Page seeded by OCA on Sat May 3 04:40:49 2008
