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3zl7

From Proteopedia

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Current revision (11:05, 20 December 2023) (edit) (undo)
 
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<StructureSection load='3zl7' size='340' side='right'caption='[[3zl7]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='3zl7' size='340' side='right'caption='[[3zl7]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zl7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZL7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zl7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZL7 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zkg|3zkg]], [[3zki|3zki]], [[3zkm|3zkm]], [[3zkn|3zkn]], [[3zkq|3zkq]], [[3zks|3zks]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_1 Memapsin 1], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.45 3.4.23.45] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zl7 OCA], [https://pdbe.org/3zl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zl7 RCSB], [https://www.ebi.ac.uk/pdbsum/3zl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zl7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zl7 OCA], [https://pdbe.org/3zl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zl7 RCSB], [https://www.ebi.ac.uk/pdbsum/3zl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zl7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/BACE2_HUMAN BACE2_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.<ref>PMID:10591213</ref> <ref>PMID:11083922</ref> <ref>PMID:15857888</ref> <ref>PMID:11423558</ref> <ref>PMID:16816112</ref>
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[https://www.uniprot.org/uniprot/BACE2_HUMAN BACE2_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.<ref>PMID:10591213</ref> <ref>PMID:11083922</ref> <ref>PMID:15857888</ref> <ref>PMID:11423558</ref> <ref>PMID:16816112</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Memapsin 1]]
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[[Category: Synthetic construct]]
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[[Category: Synthetic construct sequences]]
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[[Category: Banner DW]]
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[[Category: Banner, D W]]
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[[Category: Benz J]]
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[[Category: Benz, J]]
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[[Category: Kuglstatter A]]
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[[Category: Kuglstatter, A]]
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[[Category: Ruf A]]
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[[Category: Ruf, A]]
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[[Category: Stihle M]]
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[[Category: Stihle, M]]
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[[Category: Aspartyl protease]]
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[[Category: Hydrolase]]
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Current revision

BACE2 FYNOMER COMPLEX

PDB ID 3zl7

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