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3zlg

From Proteopedia

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Current revision (11:05, 20 December 2023) (edit) (undo)
 
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<StructureSection load='3zlg' size='340' side='right'caption='[[3zlg]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3zlg' size='340' side='right'caption='[[3zlg]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zlg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Strp6 Strp6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZLG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zlg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_MGAS10394 Streptococcus pyogenes MGAS10394]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZLG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zlf|3zlf]], [[3zlh|3zlh]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphopyruvate_hydratase Phosphopyruvate hydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.11 4.2.1.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zlg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zlg OCA], [https://pdbe.org/3zlg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zlg RCSB], [https://www.ebi.ac.uk/pdbsum/3zlg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zlg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zlg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zlg OCA], [https://pdbe.org/3zlg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zlg RCSB], [https://www.ebi.ac.uk/pdbsum/3zlg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zlg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ENO_STRP6 ENO_STRP6]] Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. Binds plasminogen when expressed on the bacterial cell surface, potentially allowing the bacterium to acquire surface-associated proteolytic activity, which in turn contributes to tissue invasion and virulence.<ref>PMID:9603964</ref>
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[https://www.uniprot.org/uniprot/ENO_STRP6 ENO_STRP6] Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. Binds plasminogen when expressed on the bacterial cell surface, potentially allowing the bacterium to acquire surface-associated proteolytic activity, which in turn contributes to tissue invasion and virulence.<ref>PMID:9603964</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Phosphopyruvate hydratase]]
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[[Category: Streptococcus pyogenes MGAS10394]]
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[[Category: Strp6]]
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[[Category: Aquilina JA]]
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[[Category: Aquilina, J A]]
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[[Category: Bertozzi C]]
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[[Category: Bertozzi, C]]
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[[Category: Casey LW]]
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[[Category: Casey, L W]]
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[[Category: Cork AJ]]
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[[Category: Cork, A J]]
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[[Category: Ericsson DJ]]
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[[Category: Ericsson, D J]]
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[[Category: Kobe B]]
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[[Category: Kobe, B]]
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[[Category: Law RHP]]
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[[Category: Law, R H.P]]
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[[Category: Stamp A]]
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[[Category: Stamp, A]]
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[[Category: Valkov E]]
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[[Category: Valkov, E]]
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[[Category: Walker MJ]]
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[[Category: Walker, M J]]
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[[Category: Whisstock JC]]
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[[Category: Whisstock, J C]]
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[[Category: Lyase]]
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[[Category: Plasminogen-binding]]
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Current revision

Structure of group A Streptococcal enolase K362A mutant

PDB ID 3zlg

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Proteopedia Page Contributors and Editors (what is this?)

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