3zqs

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Current revision (11:10, 20 December 2023) (edit) (undo)
 
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<StructureSection load='3zqs' size='340' side='right'caption='[[3zqs]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3zqs' size='340' side='right'caption='[[3zqs]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZQS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZQS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqs OCA], [https://pdbe.org/3zqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zqs RCSB], [https://www.ebi.ac.uk/pdbsum/3zqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zqs OCA], [https://pdbe.org/3zqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zqs RCSB], [https://www.ebi.ac.uk/pdbsum/3zqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zqs ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN]] Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.<ref>PMID:12973351</ref> <ref>PMID:16916645</ref> <ref>PMID:17938197</ref> <ref>PMID:19111657</ref> <ref>PMID:19589784</ref>
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[https://www.uniprot.org/uniprot/FANCL_HUMAN FANCL_HUMAN] Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.<ref>PMID:12973351</ref> <ref>PMID:16916645</ref> <ref>PMID:17938197</ref> <ref>PMID:19111657</ref> <ref>PMID:19589784</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ubiquitin--protein ligase]]
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[[Category: Cole AR]]
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[[Category: Cole, A R]]
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[[Category: Hodson C]]
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[[Category: Hodson, C]]
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[[Category: Purkiss-Trew A]]
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[[Category: Purkiss-Trew, A]]
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[[Category: Walden H]]
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[[Category: Walden, H]]
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[[Category: Ligase]]
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Current revision

Human FANCL central domain

PDB ID 3zqs

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