3zuo

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<StructureSection load='3zuo' size='340' side='right'caption='[[3zuo]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
<StructureSection load='3zuo' size='340' side='right'caption='[[3zuo]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zuo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Argasid_tick Argasid tick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZUO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zuo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ornithodoros_moubata Ornithodoros moubata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZUO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LTB:LEUKOTRIENE+B4'>LTB</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cm9|2cm9]], [[2cm4|2cm4]], [[3zui|3zui]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LTB:LEUKOTRIENE+B4'>LTB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuo OCA], [https://pdbe.org/3zuo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zuo RCSB], [https://www.ebi.ac.uk/pdbsum/3zuo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zuo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuo OCA], [https://pdbe.org/3zuo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zuo RCSB], [https://www.ebi.ac.uk/pdbsum/3zuo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zuo ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/C5I_ORNMO C5I_ORNMO] Bifunctional protein derived from blood-feeding ticks that specifically prevents complement-mediated C5 activation and acts as a scavenger for inflammatory modulators such as leukotriene B4 (LTB4). C5 and LTB4 binding activities are independent (PubMed:23625922). Inhibits classical and alternative pathways of complement activation by preventing the cleavage of complement C5 by both classical and alternative C5 convertases (PubMed:15699138) (Probable). Inhibits complement in all species tested (rabbit, rat, guinea pig, mouse, pig, and human) (PubMed:27018802). Also binds fatty acids such as palmitoleic acid and ricinoleic acid, as well as inflammatory modulators LTB4 (and presumably arachidonic acid (AA)) that may be sequestered to interfere with the host inflammatory response (PubMed:23625922). Does not bind to leukotriene C4 and thromboxane B2 (PubMed:23625922). In vivo, when tested on the mouse model of immune complex-induced acute lung injury (IC-ALI), shows a potent inhibitory activity of the pathology, equally dependent on both C5 inhibition and LTB4 binding for full activity (PubMed:23625922).<ref>PMID:15699138</ref> <ref>PMID:23625922</ref> <ref>PMID:27018802</ref> <ref>PMID:17445829</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Argasid tick]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ahmat, N]]
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[[Category: Ornithodoros moubata]]
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[[Category: Boland, W]]
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[[Category: Ahmat N]]
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[[Category: Caesar, J J.E]]
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[[Category: Boland W]]
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[[Category: Couillin, I]]
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[[Category: Caesar JJE]]
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[[Category: Lea, S M]]
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[[Category: Couillin I]]
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[[Category: Leonhartsberger, S]]
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[[Category: Lea SM]]
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[[Category: Lissina, O]]
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[[Category: Leonhartsberger S]]
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[[Category: Maillet, I]]
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[[Category: Lissina O]]
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[[Category: Nunn, M A]]
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[[Category: Maillet I]]
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[[Category: Ploss, K]]
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[[Category: Nunn MA]]
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[[Category: Quesniaux, V F.J]]
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[[Category: Ploss K]]
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[[Category: Roversi, P]]
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[[Category: Quesniaux VFJ]]
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[[Category: Ryffel, B]]
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[[Category: Roversi P]]
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[[Category: Teixeira, M]]
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[[Category: Ryffel B]]
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[[Category: Togbe, D]]
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[[Category: Teixeira M]]
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[[Category: Immune system]]
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[[Category: Togbe D]]

Revision as of 11:13, 20 December 2023

OMCI in complex with leukotriene B4

PDB ID 3zuo

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