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4a32

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Current revision (11:18, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4a32' size='340' side='right'caption='[[4a32]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4a32' size='340' side='right'caption='[[4a32]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4a32]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A32 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4a32]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A32 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CD:3,5-DICHLORO-3-[(DIETHYLAMINO)METHYL]-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BIPHENYL-4-SULFONAMIDE'>2CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4a33|4a33]], [[4a30|4a30]], [[2wsa|2wsa]], [[4a2z|4a2z]], [[4a31|4a31]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CD:3,5-DICHLORO-3-[(DIETHYLAMINO)METHYL]-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BIPHENYL-4-SULFONAMIDE'>2CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a32 OCA], [https://pdbe.org/4a32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a32 RCSB], [https://www.ebi.ac.uk/pdbsum/4a32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a32 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a32 OCA], [https://pdbe.org/4a32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a32 RCSB], [https://www.ebi.ac.uk/pdbsum/4a32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a32 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
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[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glycylpeptide N-tetradecanoyltransferase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Leima]]
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[[Category: Leishmania major]]
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[[Category: Brand, S]]
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[[Category: Brand S]]
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[[Category: Brenk, R]]
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[[Category: Brenk R]]
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[[Category: Cleghorn, L A.T]]
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[[Category: Cleghorn LAT]]
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[[Category: Fairlamb, A H]]
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[[Category: Fairlamb AH]]
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[[Category: Ferguson, M A.J]]
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[[Category: Ferguson MAJ]]
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[[Category: Frearson, J A]]
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[[Category: Frearson JA]]
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[[Category: Gilbert, I H]]
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[[Category: Gilbert IH]]
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[[Category: Hallyburton, I]]
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[[Category: Hallyburton I]]
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[[Category: Harrison, J R]]
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[[Category: Harrison JR]]
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[[Category: McElroy, S P]]
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[[Category: McElroy SP]]
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[[Category: Norcross, N R]]
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[[Category: Norcross NR]]
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[[Category: Norval, S]]
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[[Category: Norval S]]
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[[Category: Read, K D]]
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[[Category: Read KD]]
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[[Category: Robinson, D A]]
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[[Category: Robinson DA]]
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[[Category: Smith, V C]]
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[[Category: Smith VC]]
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[[Category: Spinks, D]]
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[[Category: Spinks D]]
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[[Category: Stojanovski, L]]
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[[Category: Stojanovski L]]
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[[Category: Torrie, L S]]
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[[Category: Torrie LS]]
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[[Category: Wyatt, P G]]
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[[Category: Wyatt PG]]
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[[Category: Acyltransferase]]
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[[Category: Drug discovery]]
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[[Category: Leishmaniasis]]
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[[Category: Transferase]]
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Current revision

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND

PDB ID 4a32

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