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4aei

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Current revision (11:25, 20 December 2023) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4aei]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_australis_hector Androctonus australis hector] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AEI FirstGlance]. <br>
<table><tr><td colspan='2'>[[4aei]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_australis_hector Androctonus australis hector] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AEI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1seg|1seg]], [[1ptx|1ptx]], [[1aho|1aho]], [[4aeh|4aeh]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aei OCA], [https://pdbe.org/4aei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aei RCSB], [https://www.ebi.ac.uk/pdbsum/4aei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aei ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aei OCA], [https://pdbe.org/4aei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aei RCSB], [https://www.ebi.ac.uk/pdbsum/4aei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aei ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SCX2_ANDAU SCX2_ANDAU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals.
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[https://www.uniprot.org/uniprot/SCX2_ANDAU SCX2_ANDAU] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Bourne, Y]]
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[[Category: Bourne Y]]
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[[Category: Conrod, S]]
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[[Category: Conrod S]]
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[[Category: Fabrichny, I P]]
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[[Category: Fabrichny IP]]
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[[Category: Marchot, P]]
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[[Category: Marchot P]]
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[[Category: Martin-Eauclaire, M F]]
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[[Category: Martin-Eauclaire MF]]
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[[Category: Mondielli, G]]
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[[Category: Mondielli G]]
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[[Category: Alpha-toxin]]
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[[Category: Combining site]]
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[[Category: Conformational rearrangement]]
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[[Category: Epitope]]
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[[Category: Immune system-toxin complex]]
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[[Category: Pharmacological site]]
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[[Category: Venom]]
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[[Category: Voltage-activated sodium channel]]
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Current revision

Crystal structure of the AaHII-Fab4C1 complex

PDB ID 4aei

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