4ael

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Current revision (11:25, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4ael' size='340' side='right'caption='[[4ael]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4ael' size='340' side='right'caption='[[4ael]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AEL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AEL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2y5v|2y5v]], [[1lrb|1lrb]], [[2wey|2wey]], [[2y5x|2y5x]], [[2y5u|2y5u]], [[2y0j|2y0j]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [https://pdbe.org/4ael PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [https://www.ebi.ac.uk/pdbsum/4ael PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ael ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [https://pdbe.org/4ael PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [https://www.ebi.ac.uk/pdbsum/4ael PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ael ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bauer, M]]
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[[Category: Bauer M]]
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[[Category: Bauer, U]]
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[[Category: Bauer U]]
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[[Category: Carlsson, E Toppner]]
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[[Category: Enroth C]]
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[[Category: Enroth, C]]
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[[Category: Giordanetto F]]
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[[Category: Giordanetto, F]]
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[[Category: Hartleib-Geschwindner J]]
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[[Category: Hartleib-Geschwindner, J]]
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[[Category: Johansson KE]]
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[[Category: Johansson, K E]]
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[[Category: Knecht W]]
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[[Category: Knecht, W]]
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[[Category: OMahony G]]
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[[Category: OMahony, G]]
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[[Category: Sjogren T]]
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[[Category: Sjogren, T]]
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[[Category: Toppner Carlsson E]]
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[[Category: Enzyme inhibitor]]
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[[Category: Hit-to-lead]]
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[[Category: Hydrolase]]
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[[Category: Naphtyridine]]
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Current revision

PDE10A in complex with the inhibitor AZ5

PDB ID 4ael

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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