1qqw

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Revision as of 16:49, 12 November 2007

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spinqualitylabelsall models 1qqw, resolution 2.75Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CRYSTAL STRUCTURE OF HUMAN ERYTHROCYTE CATALASE

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Catalase (E.C. 1.11.1.6) was purified from human erythrocytes and, crystallized in three different forms: orthorhombic, hexagonal and, tetragonal. The structure of the orthorhombic crystal form of human, erythrocyte catalase (HEC), with space group P2(1)2(1)2(1) and unit-cell, parameters a = 84.9, b = 141.7, c = 232.5 A, was determined and refined, with 2.75 A resolution data. Non-crystallographic symmetry restraints were, employed and the resulting R value and R(free) were 0.206 and 0.272, respectively. The overall structure and arrangement of HEC molecules in, the orthorhombic unit cell were very similar to those of bovine liver, catalase (BLC). However, no NADPH was observed in the HEC crystal and a, water was bound to the active-site residue His75. Conserved lattice, interactions suggested a common growth mechanism for the orthorhombic, crystals of HEC and BLC.

Disease

Known disease associated with this structure: Acatalasemia OMIM:[115500]

About this Structure

1QQW is a Single protein structure of sequence from Homo sapiens with HEM as ligand. The following page contains interesting information on the relation of 1QQW with [Catalase]. Active as Catalase, with EC number 1.11.1.6 Full crystallographic information is available from OCA.

Reference

Structure of human erythrocyte catalase., Ko TP, Safo MK, Musayev FN, Di Salvo ML, Wang C, Wu SH, Abraham DJ, Acta Crystallogr D Biol Crystallogr. 2000 Feb;56(Pt 2):241-5. PMID:10666617

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