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4ami

From Proteopedia

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Current revision (11:30, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4ami' size='340' side='right'caption='[[4ami]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='4ami' size='340' side='right'caption='[[4ami]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ami]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Melga Melga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AMI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ami]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AMI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=G90:2-[(2S)-3-[[1-(1H-INDOL-3-YL)-2-METHYL-PROPAN-2-YL]AMINO]-2-OXIDANYL-PROPOXY]BENZENECARBONITRILE'>G90</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dep|1dep]], [[2vt4|2vt4]], [[2y00|2y00]], [[2y01|2y01]], [[2y02|2y02]], [[2y03|2y03]], [[2y04|2y04]], [[2ycw|2ycw]], [[2ycx|2ycx]], [[2ycy|2ycy]], [[2ycz|2ycz]], [[4amj|4amj]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=G90:2-[(2S)-3-[[1-(1H-INDOL-3-YL)-2-METHYL-PROPAN-2-YL]AMINO]-2-OXIDANYL-PROPOXY]BENZENECARBONITRILE'>G90</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ami FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ami OCA], [https://pdbe.org/4ami PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ami RCSB], [https://www.ebi.ac.uk/pdbsum/4ami PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ami ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ami FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ami OCA], [https://pdbe.org/4ami PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ami RCSB], [https://www.ebi.ac.uk/pdbsum/4ami PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ami ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
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[https://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Melga]]
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[[Category: Meleagris gallopavo]]
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[[Category: Edwards, P C]]
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[[Category: Edwards PC]]
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[[Category: Leslie, A G]]
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[[Category: Leslie AG]]
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[[Category: Tate, C G]]
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[[Category: Tate CG]]
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[[Category: Warne, T]]
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[[Category: Warne T]]
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[[Category: 7tmr beta1-adrenoceptor]]
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[[Category: Biased agonist]]
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[[Category: Membrane protein]]
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[[Category: Stabilising mutation]]
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Current revision

Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol

PDB ID 4ami

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