4anj

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<StructureSection load='4anj' size='340' side='right'caption='[[4anj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4anj' size='340' side='right'caption='[[4anj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4anj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeqvi Aeqvi] and [https://en.wikipedia.org/wiki/Drome Drome]. The June 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''GFP-like Proteins'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_6 10.2210/rcsb_pdb/mom_2014_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ANJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4anj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria], [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. The June 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''GFP-like Proteins'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_6 10.2210/rcsb_pdb/mom_2014_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ANJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CR2:{(4Z)-2-(AMINOMETHYL)-4-[(4-HYDROXYPHENYL)METHYLIDENE]-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>CR2</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CR2:{(4Z)-2-(AMINOMETHYL)-4-[(4-HYDROXYPHENYL)METHYLIDENE]-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>CR2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1b9c|1b9c]], [[1bfp|1bfp]], [[1c4f|1c4f]], [[1cv7|1cv7]], [[1ema|1ema]], [[1emb|1emb]], [[1emc|1emc]], [[1eme|1eme]], [[1emf|1emf]], [[1emg|1emg]], [[1emk|1emk]], [[1eml|1eml]], [[1emm|1emm]], [[1f09|1f09]], [[1f0b|1f0b]], [[1gfl|1gfl]], [[1h6r|1h6r]], [[1hcj|1hcj]], [[1huy|1huy]], [[1jby|1jby]], [[1jbz|1jbz]], [[1jc0|1jc0]], [[1jc1|1jc1]], [[1kp5|1kp5]], [[1kyp|1kyp]], [[1kyr|1kyr]], [[1kys|1kys]], [[1mxe|1mxe]], [[1myw|1myw]], [[1q4a|1q4a]], [[1q4b|1q4b]], [[1q4c|1q4c]], [[1q4d|1q4d]], [[1q4e|1q4e]], [[1q73|1q73]], [[1qxt|1qxt]], [[1qy3|1qy3]], [[1qyf|1qyf]], [[1qyo|1qyo]], [[1qyq|1qyq]], [[1rm9|1rm9]], [[1rmm|1rmm]], [[1rmo|1rmo]], [[1rmp|1rmp]], [[1rrx|1rrx]], [[1w7s|1w7s]], [[1w7t|1w7t]], [[1w7u|1w7u]], [[1yfp|1yfp]], [[1yhg|1yhg]], [[1yhh|1yhh]], [[1yhi|1yhi]], [[1yj2|1yj2]], [[1yjf|1yjf]], [[1z1p|1z1p]], [[1z1q|1z1q]], [[2ah8|2ah8]], [[2aha|2aha]], [[2b3p|2b3p]], [[2b3q|2b3q]], [[2bbm|2bbm]], [[2bbn|2bbn]], [[2bkh|2bkh]], [[2bki|2bki]], [[2emd|2emd]], [[2emn|2emn]], [[2emo|2emo]], [[2fwq|2fwq]], [[2fzu|2fzu]], [[2v26|2v26]], [[2vas|2vas]], [[2vb6|2vb6]], [[2wsn|2wsn]], [[2wso|2wso]], [[2wur|2wur]], [[2x51|2x51]], [[2y0g|2y0g]], [[2ydz|2ydz]], [[2ye0|2ye0]], [[2ye1|2ye1]], [[2yfp|2yfp]], [[3ztf|3ztf]], [[4cln|4cln]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4anj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4anj OCA], [https://pdbe.org/4anj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4anj RCSB], [https://www.ebi.ac.uk/pdbsum/4anj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4anj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4anj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4anj OCA], [https://pdbe.org/4anj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4anj RCSB], [https://www.ebi.ac.uk/pdbsum/4anj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4anj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref> [[https://www.uniprot.org/uniprot/CALM_DROME CALM_DROME]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
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[https://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref> [https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aeqvi]]
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[[Category: Aequorea victoria]]
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
[[Category: GFP-like Proteins]]
[[Category: GFP-like Proteins]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Houdusse, A M]]
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[[Category: Sus scrofa]]
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[[Category: Isabet, T]]
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[[Category: Houdusse AM]]
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[[Category: Liu, X]]
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[[Category: Isabet T]]
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[[Category: Menetrey, J]]
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[[Category: Liu X]]
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[[Category: Mukherjea, M]]
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[[Category: Menetrey J]]
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[[Category: Perez, J]]
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[[Category: Mukherjea M]]
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[[Category: Pylypenko, O]]
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[[Category: Perez J]]
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[[Category: Ropars, V]]
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[[Category: Pylypenko O]]
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[[Category: Sweeney, H L]]
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[[Category: Ropars V]]
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[[Category: Vachette, P]]
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[[Category: Sweeney HL]]
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[[Category: Gfp fusion]]
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[[Category: Vachette P]]
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[[Category: Metal-binding protein]]
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[[Category: Molecular motor]]
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[[Category: Motor protein-metal-bindng protein complex]]
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[[Category: Pre-powerstroke state]]
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[[Category: Transition state]]
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Revision as of 11:31, 20 December 2023

MYOSIN VI (MDinsert2-GFP fusion) PRE-POWERSTROKE STATE (MG.ADP.AlF4)

PDB ID 4anj

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