4apn

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Current revision (11:32, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4apn' size='340' side='right'caption='[[4apn]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='4apn' size='340' side='right'caption='[[4apn]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4apn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiin Leiin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4APN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4apn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_infantum Leishmania infantum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4APN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=JV0:4-[[1-(4-ETHYLPHENYL)-2-METHYL-5-(4-METHYLSULFANYLPHENYL)PYRROL-3-YL]METHYL]THIOMORPHOLINE'>JV0</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jk6|2jk6]], [[2w0h|2w0h]], [[2x50|2x50]], [[2yau|2yau]], [[4adw|4adw]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=JV0:4-[[1-(4-ETHYLPHENYL)-2-METHYL-5-(4-METHYLSULFANYLPHENYL)PYRROL-3-YL]METHYL]THIOMORPHOLINE'>JV0</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trypanothione-disulfide_reductase Trypanothione-disulfide reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.12 1.8.1.12] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4apn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4apn OCA], [https://pdbe.org/4apn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4apn RCSB], [https://www.ebi.ac.uk/pdbsum/4apn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4apn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4apn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4apn OCA], [https://pdbe.org/4apn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4apn RCSB], [https://www.ebi.ac.uk/pdbsum/4apn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4apn ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A4HSF7_LEIIN A4HSF7_LEIIN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Leiin]]
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[[Category: Leishmania infantum]]
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[[Category: Trypanothione-disulfide reductase]]
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[[Category: Baiocco P]]
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[[Category: Baiocco, P]]
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[[Category: Biava M]]
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[[Category: Biava, M]]
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[[Category: Colotti G]]
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[[Category: Colotti, G]]
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[[Category: Ilari A]]
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[[Category: Ilari, A]]
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[[Category: Oxidoreductase]]
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[[Category: Trypanosomatid]]
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Current revision

Structure of TR from Leishmania infantum in complex with a diarylpirrole-based inhibitor

PDB ID 4apn

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OCA

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