4apy
From Proteopedia
(Difference between revisions)
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<StructureSection load='4apy' size='340' side='right'caption='[[4apy]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='4apy' size='340' side='right'caption='[[4apy]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4apy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4apy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4APY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4APY FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4apy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4apy OCA], [https://pdbe.org/4apy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4apy RCSB], [https://www.ebi.ac.uk/pdbsum/4apy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4apy ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4apy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4apy OCA], [https://pdbe.org/4apy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4apy RCSB], [https://www.ebi.ac.uk/pdbsum/4apy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4apy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CP125_MYCS2 CP125_MYCS2] Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.<ref>PMID:23489718</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Bacillus smegmatis trevisan 1889]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mycolicibacterium smegmatis MC2 155]] |
| - | [[Category: Frank | + | [[Category: Frank DJ]] |
| - | [[Category: | + | [[Category: Garcia Fernandez E]] |
| - | [[Category: Lopez | + | [[Category: Garcia Lopez JL]] |
| - | [[Category: | + | [[Category: Kells PM]] |
| - | [[Category: | + | [[Category: Ortiz de Montellano PR]] |
| - | [[Category: | + | [[Category: Podust LM]] |
| - | + | ||
Current revision
Ethylene glycol-bound form of P450 CYP125A3 from Mycobacterium smegmatis
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