4aso

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Current revision (11:34, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4aso' size='340' side='right'caption='[[4aso]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
<StructureSection load='4aso' size='340' side='right'caption='[[4aso]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4aso]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_cereus_var._thuringiensis"_smith_et_al._1952 "bacillus cereus var. thuringiensis" smith et al. 1952]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4aso]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASO FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4asn|4asn]], [[4ass|4ass]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aso OCA], [https://pdbe.org/4aso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aso RCSB], [https://www.ebi.ac.uk/pdbsum/4aso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aso ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aso OCA], [https://pdbe.org/4aso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aso RCSB], [https://www.ebi.ac.uk/pdbsum/4aso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aso ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TUBR_BACTI TUBR_BACTI] A DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid. Cooperatively binds to the centromere-like site (tubC), which may seed filament formation by the TubZ polymerizing GTPase, stabilizing TubZ filaments. TubR-tubC complexes track the depolymerizing minus end of the filament, probably pulling plasmid within the cell (PubMed:20534443, PubMed:23010931, PubMed:25825718). Required for plasmid replication (PubMed:16936050, PubMed:17873046). Negatively regulates levels of TubZ; its effect on RNA expression has not been shown (Probable). Specifically binds iterons, 12-bp imperfect direct repeats that function as a plasmid origin of replication (PubMed:17873046, PubMed:23010931, PubMed:25825718). Four TubR dimers bind to tubC, forming an extended bent DNA-protein filament with protein wrapping helically around the outside of the DNA (PubMed:20534443, PubMed:23010931).<ref>PMID:16936050</ref> <ref>PMID:17873046</ref> <ref>PMID:20534443</ref> <ref>PMID:23010931</ref> <ref>PMID:25825718</ref> <ref>PMID:17510284</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus cereus var. thuringiensis smith et al. 1952]]
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[[Category: Bacillus thuringiensis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Aylett, C H.S]]
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[[Category: Aylett CHS]]
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[[Category: Lowe, J]]
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[[Category: Lowe J]]
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[[Category: Partition]]
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[[Category: Segregation]]
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[[Category: Structural protein-dna complex]]
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Current revision

TubR bound to 24 bp of tubC from Bacillus thuringiensis serovar israelensis pBtoxis

PDB ID 4aso

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