4b65

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:44, 20 December 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='4b65' size='340' side='right'caption='[[4b65]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
<StructureSection load='4b65' size='340' side='right'caption='[[4b65]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4b65]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspfm Aspfm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B65 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4b65]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B65 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4b63|4b63]], [[4b64|4b64]], [[4b66|4b66]], [[4b67|4b67]], [[4b68|4b68]], [[4b69|4b69]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b65 OCA], [https://pdbe.org/4b65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b65 RCSB], [https://www.ebi.ac.uk/pdbsum/4b65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b65 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b65 OCA], [https://pdbe.org/4b65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b65 RCSB], [https://www.ebi.ac.uk/pdbsum/4b65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b65 ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SIDA_ASPFU SIDA_ASPFU] Catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores, such as the secreted triacetylfusarinine C (TAFC) involved in iron uptake and the intracellular iron storage compound desferriferricrocin (DFFC). Highly specific for its substrate, only hydrolyzing l-ornithine. Has preference for NADPH over NADH, NADPH playing a role in stabilization of the C4a-hydroperoxyflavin intermediate. Essential for virulence.<ref>PMID:15504822</ref> <ref>PMID:16113265</ref> <ref>PMID:20614882</ref> <ref>PMID:22465572</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 26:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Aspfm]]
+
[[Category: Aspergillus fumigatus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Fedkenheuer, M]]
+
[[Category: Fedkenheuer M]]
-
[[Category: Franceschini, S]]
+
[[Category: Franceschini S]]
-
[[Category: Mattevi, A]]
+
[[Category: Mattevi A]]
-
[[Category: Robinson, H H]]
+
[[Category: Robinson HH]]
-
[[Category: Sobrado, P]]
+
[[Category: Sobrado P]]
-
[[Category: Vogelaar, N J]]
+
[[Category: Vogelaar NJ]]
-
[[Category: Flavin]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Siderophore]]
+

Current revision

A. fumigatus ornithine hydroxylase (SidA), reduced state bound to NADP(H)

PDB ID 4b65

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4b65"
Personal tools