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4b7y

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Current revision (11:45, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4b7y' size='340' side='right'caption='[[4b7y]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
<StructureSection load='4b7y' size='340' side='right'caption='[[4b7y]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4b7y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B7Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4b7y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B7Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7y OCA], [https://pdbe.org/4b7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b7y RCSB], [https://www.ebi.ac.uk/pdbsum/4b7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7y ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7y OCA], [https://pdbe.org/4b7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b7y RCSB], [https://www.ebi.ac.uk/pdbsum/4b7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MSL1_HUMAN MSL1_HUMAN]] Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.<ref>PMID:16227571</ref> <ref>PMID:21726816</ref> <ref>PMID:22547026</ref> [[https://www.uniprot.org/uniprot/MSL2_HUMAN MSL2_HUMAN]] Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.<ref>PMID:21726816</ref>
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[https://www.uniprot.org/uniprot/MSL2_HUMAN MSL2_HUMAN] Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.<ref>PMID:21726816</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Akhtar, A]]
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[[Category: Akhtar A]]
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[[Category: Cusack, S]]
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[[Category: Cusack S]]
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[[Category: Georgiev, P]]
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[[Category: Georgiev P]]
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[[Category: Hallacli, E]]
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[[Category: Hallacli E]]
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[[Category: Kadlec, J]]
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[[Category: Kadlec J]]
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[[Category: Lipp, M]]
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[[Category: Lipp M]]
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[[Category: Spielman, C]]
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[[Category: Spielman C]]
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[[Category: Chromatin]]
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[[Category: Dosage compensation]]
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[[Category: Gene regulation]]
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Current revision

Crystal structure of the MSL1-MSL2 complex

PDB ID 4b7y

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