4bbm

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Current revision (11:47, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4bbm' size='340' side='right'caption='[[4bbm]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4bbm' size='340' side='right'caption='[[4bbm]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bbm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BBM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bbm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BBM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TC0:4-[5-[[3-[(CYCLOPROPYLAMINO)METHYL]PHENYL]AMINO]-1H-PYRAZOL-3-YL]-[1,1-BIPHENYL]-2,4-DIOL'>TC0</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4aaa|4aaa]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TC0:4-[5-[[3-[(CYCLOPROPYLAMINO)METHYL]PHENYL]AMINO]-1H-PYRAZOL-3-YL]-[1,1-BIPHENYL]-2,4-DIOL'>TC0</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bbm OCA], [https://pdbe.org/4bbm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bbm RCSB], [https://www.ebi.ac.uk/pdbsum/4bbm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bbm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bbm OCA], [https://pdbe.org/4bbm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bbm RCSB], [https://www.ebi.ac.uk/pdbsum/4bbm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bbm ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CDKL2_HUMAN CDKL2_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cyclin-dependent kinase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Berridge, G]]
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[[Category: Berridge G]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Bullock, A]]
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[[Category: Bullock A]]
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[[Category: Burgess-Brown, N]]
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[[Category: Burgess-Brown N]]
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[[Category: Canning, P]]
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[[Category: Canning P]]
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[[Category: Cooper, C D.O]]
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[[Category: Cooper CDO]]
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[[Category: Daga, N]]
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[[Category: Daga N]]
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[[Category: Delft, F von]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M]]
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[[Category: Elkins JM]]
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[[Category: Elkins, J M]]
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[[Category: Krojer T]]
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[[Category: Krojer, T]]
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[[Category: Mahajan P]]
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[[Category: Mahajan, P]]
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[[Category: Muniz JRC]]
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[[Category: Muniz, J R.C]]
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[[Category: Von Delft F]]
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[[Category: Phospho-mimetic]]
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[[Category: Transferase]]
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Current revision

CRYSTAL STRUCTURE OF THE HUMAN CDKL2 KINASE DOMAIN WITH BOUND TCS 2312

PDB ID 4bbm

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