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4bhk

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Crystal Structure of Moss Leafy bound to DNA

Structural highlights

4bhk is a 4 chain structure with sequence from Physcomitrium patens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.32Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q94IF5_PHYPA

Publication Abstract from PubMed

Transcription factors are key players in evolution. Changes affecting their function can yield novel life forms but also have deleterious effects. Consequently, gene duplication events that release one gene copy from selective pressure are thought to be the common mechanism by which transcription factors acquire new activities. Here we show that LEAFY, a major regulator of flower development and cell division in land plants, underwent changes to its DNA binding specificity, even though plant genomes generally contain a single copy of LEAFY. We examined how these changes occurred at the structural level, and identify an intermediate LEAFY form in hornworts that appears to adopt all different specificities. This promiscuous intermediate could have smoothed the evolutionary transitions thereby allowing LEAFY to evolve new binding specificities while remaining a single copy gene.

A Promiscuous Intermediate Underlies the Evolution of LEAFY DNA Binding Specificity.,Sayou C, Monniaux M, Nanao MH, Moyroud E, Brockington SF, Thevenon E, Chahtane H, Warthmann N, Melkonian M, Zhang Y, Wong GK, Weigel D, Parcy F, Dumas R Science. 2014 Jan 16. PMID:24436181^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Sayou C, Monniaux M, Nanao MH, Moyroud E, Brockington SF, Thevenon E, Chahtane H, Warthmann N, Melkonian M, Zhang Y, Wong GK, Weigel D, Parcy F, Dumas R. A Promiscuous Intermediate Underlies the Evolution of LEAFY DNA Binding Specificity. Science. 2014 Jan 16. PMID:24436181 doi:http://dx.doi.org/10.1126/science.1248229

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4bhk"

@@ Line 3: / Line 3: @@
 <StructureSection load='4bhk' size='340' side='right'caption='[[4bhk]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4bhk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Moss Moss]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BHK FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4bhk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Physcomitrium_patens Physcomitrium patens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BHK FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhk OCA], [https://pdbe.org/4bhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bhk RCSB], [https://www.ebi.ac.uk/pdbsum/4bhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bhk ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhk OCA], [https://pdbe.org/4bhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bhk RCSB], [https://www.ebi.ac.uk/pdbsum/4bhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bhk ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q94IF5_PHYPA Q94IF5_PHYPA]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 23: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Moss]]
+[[Category: Physcomitrium patens]]
-[[Category: Dumas, R]]
+[[Category: Dumas R]]
-[[Category: Nanao, M H]]
+[[Category: Nanao MH]]
-[[Category: Parcy, F]]
+[[Category: Parcy F]]
-[[Category: Sayou, C]]
+[[Category: Sayou C]]
-[[Category: Transcription-dna complex]]

4bhk

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Current revision

Crystal Structure of Moss Leafy bound to DNA

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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