1p79

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[[Image:1p79.gif|left|200px]]
[[Image:1p79.gif|left|200px]]
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{{Structure
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|PDB= 1p79 |SIZE=350|CAPTION= <scene name='initialview01'>1p79</scene>, resolution 1.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1p79", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_1p79| PDB=1p79 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p79 OCA], [http://www.ebi.ac.uk/pdbsum/1p79 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p79 RCSB]</span>
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'''Crystal structure of a bulged RNA tetraplex: implications for a novel binding site in RNA tetraplex'''
'''Crystal structure of a bulged RNA tetraplex: implications for a novel binding site in RNA tetraplex'''
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==About this Structure==
==About this Structure==
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1P79 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P79 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P79 OCA].
==Reference==
==Reference==
Crystal structure of a bulged RNA tetraplex at 1.1 a resolution: implications for a novel binding site in RNA tetraplex., Pan B, Xiong Y, Shi K, Sundaralingam M, Structure. 2003 Nov;11(11):1423-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14604532 14604532]
Crystal structure of a bulged RNA tetraplex at 1.1 a resolution: implications for a novel binding site in RNA tetraplex., Pan B, Xiong Y, Shi K, Sundaralingam M, Structure. 2003 Nov;11(11):1423-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14604532 14604532]
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[[Category: Protein complex]]
 
[[Category: Pan, B.]]
[[Category: Pan, B.]]
[[Category: Shi, K.]]
[[Category: Shi, K.]]
[[Category: Sundaralingam, M.]]
[[Category: Sundaralingam, M.]]
[[Category: Xiong, Y.]]
[[Category: Xiong, Y.]]
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[[Category: bulge]]
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[[Category: Bulge]]
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[[Category: rna]]
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[[Category: Rna]]
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[[Category: tetraplex]]
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[[Category: Tetraplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:46:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:55:54 2008''
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Revision as of 01:46, 3 May 2008

Image:1p79.gif

Template:STRUCTURE 1p79

Crystal structure of a bulged RNA tetraplex: implications for a novel binding site in RNA tetraplex


Overview

Bulges are an important structural motif in RNA and can be used as recognition and interaction sites in RNA-protein interaction and RNA-RNA interaction. Here we report the first crystal structure of a bulged RNA tetraplex at 1.1 A resolution. The hexamer r(U)(BrdG)r(UGGU) forms a parallel tetraplex with the uridine sandwiched by guanines bulging out. The bulged uridine adopts the syn glycosidic conformation and its O2 and N3 atoms face outwards, serving as an effective recognition and interaction site. The bulge formation both widens the groove width and changes the groove hydrogen-bonding pattern on its 5' side. However, the bulge does not make any bends or kinks in the tetraplex structure. The present study demonstrates the dramatic difference between uridine and guanine in forming tetraplex structure. In addition, both G(syn) tetrad and G(anti) tetrad have been observed. They display the same base-pairing pattern and similar C1'-C1' distance but different hydrogen-bonding patterns in the groove.

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a bulged RNA tetraplex at 1.1 a resolution: implications for a novel binding site in RNA tetraplex., Pan B, Xiong Y, Shi K, Sundaralingam M, Structure. 2003 Nov;11(11):1423-30. PMID:14604532 Page seeded by OCA on Sat May 3 04:46:21 2008

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