4boe

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:55, 20 December 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='4boe' size='340' side='right'caption='[[4boe]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
<StructureSection load='4boe' size='340' side='right'caption='[[4boe]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4boe]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BOE FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4boe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhipicephalus_appendiculatus Rhipicephalus appendiculatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BOE FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4boe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4boe OCA], [https://pdbe.org/4boe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4boe RCSB], [https://www.ebi.ac.uk/pdbsum/4boe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4boe ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4boe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4boe OCA], [https://pdbe.org/4boe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4boe RCSB], [https://www.ebi.ac.uk/pdbsum/4boe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4boe ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/JAP_RHIAP JAP_RHIAP] Salivary tick protein that modulates host immune response. This protein blocks dendritic cell (DC) differentiation from monocytes (PubMed:23825947). In addition, it inhibits up-regulation of costimulatory molecules and pro-inflammatory cytokines in response to stimuli and promotes up-regulation of co-inhibitory molecules and the anti-inflammatory cytokine interleukin-10 (PubMed:23825947). It has a pocket to accomodate cholesterol, which may have immune-modulatory roles, either directly or through interactions with the host gut microbiota (Probable).<ref>PMID:23825947</ref> <ref>PMID:29167574</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 24:
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Austyn, J M]]
+
[[Category: Rhipicephalus appendiculatus]]
-
[[Category: Johnson, S]]
+
[[Category: Austyn JM]]
-
[[Category: Lea, S M]]
+
[[Category: Johnson S]]
-
[[Category: Nuttall, P]]
+
[[Category: Lea SM]]
-
[[Category: Preston, S]]
+
[[Category: Nuttall P]]
-
[[Category: Roversi, P]]
+
[[Category: Preston S]]
-
[[Category: Cholesterol binding protein]]
+
[[Category: Roversi P]]
-
[[Category: Tick]]
+

Current revision

Japanin from Rhipicephalus appendiculatus bound to cholesterol: Tetragonal crystal form

PDB ID 4boe

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4boe"
Personal tools