1p7b
From Proteopedia
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'''Crystal structure of an inward rectifier potassium channel''' | '''Crystal structure of an inward rectifier potassium channel''' | ||
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[[Category: Rahman, T.]] | [[Category: Rahman, T.]] | ||
[[Category: Zimmer, J.]] | [[Category: Zimmer, J.]] | ||
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| - | [[Category: | + | [[Category: Ion conduction]] |
| - | [[Category: | + | [[Category: Transmembrane helice]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:46:31 2008'' | |
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Revision as of 01:46, 3 May 2008
Crystal structure of an inward rectifier potassium channel
Overview
The KirBac1.1 channel belongs to the inward-rectifier family of potassium channels. Here we report the structure of the entire prokaryotic Kir channel assembly, in the closed state, refined to a resolution of 3.65 angstroms. We identify the main activation gate and structural elements involved in gating. On the basis of structural evidence presented here, we suggest that gating involves coupling between the intracellular and membrane domains. This further suggests that initiation of gating by membrane or intracellular signals represents different entry points to a common mechanistic pathway.
About this Structure
1P7B is a Single protein structure of sequence from Burkholderia pseudomallei. Full crystallographic information is available from OCA.
Reference
Crystal structure of the potassium channel KirBac1.1 in the closed state., Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA, Science. 2003 Jun 20;300(5627):1922-6. Epub 2003 May 8. PMID:12738871 Page seeded by OCA on Sat May 3 04:46:31 2008
