4c92
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4c92]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C92 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4c92]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C92 FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c92 OCA], [https://pdbe.org/4c92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c92 RCSB], [https://www.ebi.ac.uk/pdbsum/4c92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c92 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.299Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c92 OCA], [https://pdbe.org/4c92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c92 RCSB], [https://www.ebi.ac.uk/pdbsum/4c92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c92 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/LSM1_YEAST LSM1_YEAST] Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step.<ref>PMID:10747033</ref> <ref>PMID:10913177</ref> <ref>PMID:10761922</ref> | |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The decay of mRNAs is a key step in eukaryotic gene expression. The cytoplasmic Lsm1-7-Pat1 complex is a conserved component of the 5'-to-3' mRNA decay pathway, linking deadenylation to decapping. Lsm1-7 is similar to the nuclear Sm complexes that bind oligo-uridine tracts in snRNAs. The 2.3 A resolution structure of S. cerevisiae Lsm1-7 shows the presence of a heptameric ring with Lsm1-2-3-6-5-7-4 topology. A distinct structural feature of the cytoplasmic Lsm ring is the C-terminal extension of Lsm1, which plugs the exit site of the central channel and approaches the RNA binding pockets. The 3.7 A resolution structure of Lsm1-7 bound to the C-terminal domain of Pat1 reveals that Pat1 recognition is not mediated by the distinguishing cytoplasmic subunit, Lsm1, but by Lsm2 and Lsm3. These results show how the auxiliary domains and the canonical Sm folds of the Lsm1-7 complex are organized in order to mediate and modulate macromolecular interactions. | ||
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| + | Architecture of the Lsm1-7-Pat1 Complex: A Conserved Assembly in Eukaryotic mRNA Turnover.,Sharif H, Conti E Cell Rep. 2013 Oct 15. pii: S2211-1247(13)00573-1. doi:, 10.1016/j.celrep.2013.10.004. PMID:24139796<ref>PMID:24139796</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4c92" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Sm-like protein|Sm-like protein]] | + | *[[Sm-like protein 3D structures|Sm-like protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Crystal structure of the yeast Lsm1-7 complex
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