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1p7q

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[[Image:1p7q.jpg|left|200px]]
[[Image:1p7q.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1p7q", creates the "Structure Box" on the page.
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|GENE= HLA-A OR HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1p7q| PDB=1p7q | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7q OCA], [http://www.ebi.ac.uk/pdbsum/1p7q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p7q RCSB]</span>
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'''Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor'''
'''Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor'''
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[[Category: Thomas, L M.]]
[[Category: Thomas, L M.]]
[[Category: Willcox, B E.]]
[[Category: Willcox, B E.]]
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[[Category: hla-a2/lir-1 complex]]
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[[Category: Hla-a2/lir-1 complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:47:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:56:03 2008''
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Revision as of 01:47, 3 May 2008

Image:1p7q.jpg

Template:STRUCTURE 1p7q

Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor


Contents

Overview

Leukocyte immunoglobulin-like receptor 1 (LIR-1), an inhibitory receptor expressed on monocytes, dendritic cells and lymphocytes, regulates cellular function by binding a broad range of classical and nonclassical major histocompatibility complex (MHC) class I molecules, and the human cytomegalovirus MHC class I homolog UL18. Here we describe the 3.4-A crystal structure of a complex between the LIR-1 D1D2 domains and the MHC class I molecule HLA-A2. LIR-1 contacts the mostly conserved beta(2)-microglobulin and alpha3 domains of HLA-A2. The LIR-1 binding site comprises residues at the interdomain hinge, and a patch at the D1 tip. The structure shows how LIR-1 recognizes UL18 and diverse MHC class I molecules, and indicates that a similar mode of MHC class I recognition is used by other LIR family members.

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1P7Q is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor., Willcox BE, Thomas LM, Bjorkman PJ, Nat Immunol. 2003 Sep;4(9):913-9. Epub 2003 Aug 3. PMID:12897781 Page seeded by OCA on Sat May 3 04:47:20 2008

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