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4p19

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Current revision (12:22, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4p19' size='340' side='right'caption='[[4p19]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
<StructureSection load='4p19' size='340' side='right'caption='[[4p19]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4p19]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P19 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4p19]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P19 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xzh|1xzh]], [[2nwl|2nwl]], [[2nww|2nww]], [[2nwx|2nwx]], [[3kbc|3kbc]], [[3v8f|3v8f]], [[3v8g|3v8g]], [[4izm|4izm]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PH1295 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70601 Pyrococcus horikoshii])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p19 OCA], [https://pdbe.org/4p19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p19 RCSB], [https://www.ebi.ac.uk/pdbsum/4p19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p19 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p19 OCA], [https://pdbe.org/4p19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p19 RCSB], [https://www.ebi.ac.uk/pdbsum/4p19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p19 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GLT_PYRHO GLT_PYRHO] Sodium-dependent, high-affinity amino acid transporter that mediates aspartate uptake (PubMed:17435767, PubMed:19380583, PubMed:17230192, Ref.11). Has only very low glutamate transport activity (PubMed:19380583, PubMed:17230192). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions, resulting in electrogenic transport (PubMed:17435767, PubMed:19380583, Ref.11). Na(+) binding enhances the affinity for aspartate (PubMed:19380583, Ref.11). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:17435767). In contrast to mammalian homologs, transport does not depend on pH or K(+) ions (PubMed:19380583).<ref>PMID:17230192</ref> <ref>PMID:17435767</ref> <ref>PMID:19380583</ref> [PDB:4P19]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pyrococcus horikoshii]]
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[[Category: Pyrococcus horikoshii OT3]]
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[[Category: Boudker, O]]
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[[Category: Boudker O]]
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[[Category: Verdon, G]]
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[[Category: Verdon G]]
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[[Category: Apo form]]
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[[Category: Inward-facing state]]
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[[Category: Membrane protein]]
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[[Category: Sodium-coupled aspartate transporter]]
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[[Category: Transport protein]]
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Current revision

Closed, apo inward-facing state of the glutamate transporter homologue GltPh

PDB ID 4p19

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