2rmx

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==Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A==
==Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A==
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<StructureSection load='2rmx' size='340' side='right'caption='[[2rmx]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2rmx' size='340' side='right'caption='[[2rmx]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2rmx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RMX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2rmx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RMX FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN6, HCP, PTP1C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmx OCA], [https://pdbe.org/2rmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rmx RCSB], [https://www.ebi.ac.uk/pdbsum/2rmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmx ProSAT], [https://www.topsan.org/Proteins/RSGI/2rmx TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmx OCA], [https://pdbe.org/2rmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rmx RCSB], [https://www.ebi.ac.uk/pdbsum/2rmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmx ProSAT], [https://www.topsan.org/Proteins/RSGI/2rmx TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN]] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref> [[https://www.uniprot.org/uniprot/NKG2A_HUMAN NKG2A_HUMAN]] Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
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[https://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Inoue M]]
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[[Category: Inoue, M]]
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[[Category: Kasai T]]
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[[Category: Kasai, T]]
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[[Category: Kigawa T]]
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[[Category: Kigawa, T]]
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[[Category: Koshiba S]]
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[[Category: Koshiba, S]]
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[[Category: Yokoyama S]]
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[[Category: Structural genomic]]
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[[Category: Yokoyama, S]]
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[[Category: Alternative splicing]]
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[[Category: Cytoplasm]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Lectin]]
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[[Category: Membrane]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Phosphorylated peptide recognition]]
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[[Category: Phosphotyrosine binding domain]]
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[[Category: Protein phosphatase]]
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[[Category: Protein-peptide complex]]
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[[Category: Receptor]]
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[[Category: Rsgi]]
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[[Category: Sh2 domain]]
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[[Category: Signal transduction]]
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[[Category: Signal-anchor]]
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[[Category: Signaling protein]]
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[[Category: Transmembrane]]
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Revision as of 12:54, 20 December 2023

Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A

PDB ID 2rmx

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