1p98

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[[Image:1p98.gif|left|200px]]
[[Image:1p98.gif|left|200px]]
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{{Structure
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|PDB= 1p98 |SIZE=350|CAPTION= <scene name='initialview01'>1p98</scene>
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The line below this paragraph, containing "STRUCTURE_1p98", creates the "Structure Box" on the page.
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|GENE= RAD23A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1p98| PDB=1p98 | SCENE= }}
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|RELATEDENTRY=[[1dv0|1DV0]], [[1ify|1IFY]], [[1f4i|1F4I]], [[1p9c|1P9C]], [[1p9d|1P9D]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p98 OCA], [http://www.ebi.ac.uk/pdbsum/1p98 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p98 RCSB]</span>
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'''High-resolution NMR structure of the Ubl-domain of HHR23A'''
'''High-resolution NMR structure of the Ubl-domain of HHR23A'''
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[[Category: Feigon, J.]]
[[Category: Feigon, J.]]
[[Category: Mueller, T D.]]
[[Category: Mueller, T D.]]
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[[Category: ubiquitin-like domain]]
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[[Category: Ubiquitin-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:50:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:56:41 2008''
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Revision as of 01:50, 3 May 2008

Image:1p98.gif

Template:STRUCTURE 1p98

High-resolution NMR structure of the Ubl-domain of HHR23A


Overview

HHR23A, a protein implicated in nucleotide excision repair, belongs to a class of proteins containing both a ubiquitin-like (Ubl) domain and one or more ubiquitin-associated (UBA) domains, suggesting a role in the ubiquitin-proteasome pathway as well. The Ubl domain binds with high affinity to the second ubiquitin-interacting motif (UIM) of the S5a subunit of the proteasome. Here we present the solution structures of the HHR23A Ubl domain, the second UIM of S5a (UIM-2), and the Ubl:S5a-UIM-2 complex. The HHR23A Ubl domain is structurally similar to ubiquitin. The S5a UIM forms an alpha-helix with an unexpected hairpin loop that contributes to the binding interface with Ubl. The molecular determinants of the Ubl-proteasome interaction are revealed by analysis of the structures, chemical shift mapping, mutant binding studies and sequence conservation.

About this Structure

1P98 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural determinants for the binding of ubiquitin-like domains to the proteasome., Mueller TD, Feigon J, EMBO J. 2003 Sep 15;22(18):4634-45. PMID:12970176 Page seeded by OCA on Sat May 3 04:50:32 2008

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