1p9x

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[[Image:1p9x.gif|left|200px]]
[[Image:1p9x.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1p9x |SIZE=350|CAPTION= <scene name='initialview01'>1p9x</scene>, resolution 3.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1p9x", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=TEL:TELITHROMYCIN'>TEL</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1p9x| PDB=1p9x | SCENE= }}
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|RELATEDENTRY=[[1nkw|1NKW]], [[1njm|1NJM]], [[1njn|1NJN]], [[1jzy|1JZY]], [[1jzx|1JZX]], [[1ond|1OND]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9x OCA], [http://www.ebi.ac.uk/pdbsum/1p9x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p9x RCSB]</span>
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}}
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'''THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC'''
'''THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC'''
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[[Category: Yonath, A.]]
[[Category: Yonath, A.]]
[[Category: Zarivach, R.]]
[[Category: Zarivach, R.]]
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[[Category: antibiotic]]
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[[Category: Antibiotic]]
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[[Category: blockage]]
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[[Category: Blockage]]
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[[Category: exit-tunnel]]
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[[Category: Exit-tunnel]]
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[[Category: ketolide]]
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[[Category: Ketolide]]
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[[Category: macrolide]]
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[[Category: Macrolide]]
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[[Category: ribosome]]
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[[Category: Ribosome]]
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[[Category: trna]]
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[[Category: Trna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:52:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:56:56 2008''
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Revision as of 01:52, 3 May 2008

Image:1p9x.gif

Template:STRUCTURE 1p9x

THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC


Overview

The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.

About this Structure

1P9X is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Structural insight into the antibiotic action of telithromycin against resistant mutants., Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A, J Bacteriol. 2003 Jul;185(14):4276-9. PMID:12837804 Page seeded by OCA on Sat May 3 04:52:06 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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