1pau

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1pau.gif|left|200px]]
[[Image:1pau.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1pau |SIZE=350|CAPTION= <scene name='initialview01'>1pau</scene>, resolution 2.5&Aring;
+
The line below this paragraph, containing "STRUCTURE_1pau", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=S1:Inhibitor+Binding+Sub-Site+S1'>S1</scene>, <scene name='pdbsite=S2:Inhibitor+Binding+Sub-Site+S2'>S2</scene>, <scene name='pdbsite=S3:Inhibitor+Binding+Sub-Site+S3'>S3</scene> and <scene name='pdbsite=S4:Inhibitor+Binding+Sub-Site+S4'>S4</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1pau| PDB=1pau | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pau OCA], [http://www.ebi.ac.uk/pdbsum/1pau PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pau RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF THE COMPLEX OF APOPAIN WITH THE TETRAPEPTIDE ALDEHYDE INHIBITOR AC-DEVD-CHO'''
'''CRYSTAL STRUCTURE OF THE COMPLEX OF APOPAIN WITH THE TETRAPEPTIDE ALDEHYDE INHIBITOR AC-DEVD-CHO'''
Line 28: Line 25:
[[Category: Becker, J W.]]
[[Category: Becker, J W.]]
[[Category: Rotonda, J.]]
[[Category: Rotonda, J.]]
-
[[Category: apopain]]
+
[[Category: Apopain]]
-
[[Category: caspase-3]]
+
[[Category: Caspase-3]]
-
[[Category: complex (protease/inhibitor)]]
+
[[Category: Cpp32]]
-
[[Category: cpp32]]
+
[[Category: Cysteine protease]]
-
[[Category: cysteine protease]]
+
[[Category: Yama]]
-
[[Category: yama]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:53:28 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:57:16 2008''
+

Revision as of 01:53, 3 May 2008

Image:1pau.gif

Template:STRUCTURE 1pau

CRYSTAL STRUCTURE OF THE COMPLEX OF APOPAIN WITH THE TETRAPEPTIDE ALDEHYDE INHIBITOR AC-DEVD-CHO


Overview

Cysteine proteases related to mammalian interleukin-1 beta converting enzyme (ICE) and to its Caenorhabditis elegans homologue, CED-3, play a critical role in the biochemical events that culminate in apoptosis. We have determined the three-dimensional structure of a complex of the human CED-3 homologue CPP32/apopain with a potent tetrapeptide-aldehyde inhibitor. The protein resembles ICE in overall structure, but its S4 subsite is strikingly different in size and chemical composition. These differences account for the variation in specificity between the ICE- and CED-3-related proteases and enable the design of specific inhibitors that can probe the physiological functions of the proteins and disease states with which they are associated.

About this Structure

1PAU is a Protein complex structure of sequences from Homo sapiens. The following page contains interesting information on the relation of 1PAU with [Caspases]. Full crystallographic information is available from OCA.

Reference

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis., Rotonda J, Nicholson DW, Fazil KM, Gallant M, Gareau Y, Labelle M, Peterson EP, Rasper DM, Ruel R, Vaillancourt JP, Thornberry NA, Becker JW, Nat Struct Biol. 1996 Jul;3(7):619-25. PMID:8673606 Page seeded by OCA on Sat May 3 04:53:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pau"
Personal tools