1pax

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[[Image:1pax.gif|left|200px]]
[[Image:1pax.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1pax |SIZE=350|CAPTION= <scene name='initialview01'>1pax</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1pax", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DHQ:3,4-DIHYDRO-5-METHYL-ISOQUINOLINONE'>DHQ</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1pax| PDB=1pax | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pax OCA], [http://www.ebi.ac.uk/pdbsum/1pax PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pax RCSB]</span>
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}}
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'''THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH 3,4-DIHYDRO-5-METHYL-ISOQUINOLINONE'''
'''THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH 3,4-DIHYDRO-5-METHYL-ISOQUINOLINONE'''
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Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken., Ruf A, Mennissier de Murcia J, de Murcia G, Schulz GE, Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7481-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8755499 8755499]
Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken., Ruf A, Mennissier de Murcia J, de Murcia G, Schulz GE, Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7481-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8755499 8755499]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: NAD(+) ADP-ribosyltransferase]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Ruf, A.]]
[[Category: Ruf, A.]]
[[Category: Schulz, G E.]]
[[Category: Schulz, G E.]]
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[[Category: glycosyltransferase]]
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[[Category: Glycosyltransferase]]
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[[Category: nad(+) adp-ribosyltransferase]]
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[[Category: Transferase]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:53:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:57:14 2008''
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Revision as of 01:53, 3 May 2008

Image:1pax.gif

Template:STRUCTURE 1pax

THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH 3,4-DIHYDRO-5-METHYL-ISOQUINOLINONE


Overview

The crystal structures of the catalytic fragment of chicken poly(ADP-ribose) polymerase [NAD+ ADP-ribosyltransferase; NAD+:poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyltransferase, EC 2.4.2.30] with and without a nicotinamide-analogue inhibitor have been elucidated. Because this enzyme is involved in the regulation of DNA repair, its inhibitors are of interest for cancer therapy. The inhibitor shows the nicotinamide site and also suggests the adenosine site. The enzyme is structurally related to bacterial ADP-ribosylating toxins but contains an additional alpha-helical domain that is suggested to relay the activation signal issued on binding to damaged DNA.

About this Structure

1PAX is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken., Ruf A, Mennissier de Murcia J, de Murcia G, Schulz GE, Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7481-5. PMID:8755499 Page seeded by OCA on Sat May 3 04:53:34 2008

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