1r02

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Revision as of 16:51, 12 November 2007

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Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Orexin-A and orexin-B (hypocretin-1 and hypocretin-2, respectively) are, important hypothalamic neuro-peptides, which are encoded by a single mRNA, transcript and stimulate food intake as well as regulate wakefulness. Here, we determined the solution structure of orexin-A by NMR spectroscopy and, by simulated-annealing calculation. The structural features of orexin-A, involve two alpha-helices, with the hydrophobic residues disposed to on, one side of helix, and hydrophilic residues to the other. A hydrophilic, turn induced by two disulfide bonds provides the key difference between, orexin-A and -B. With previous mutagenic studies, the derived structure of, orexin-A provides us with a structure-functional view for novel drug, design.

Disease

Known diseases associated with this structure: Narcolepsy OMIM:[602358], Porphyria variegata OMIM:[600923]

About this Structure

1R02 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

Solution structure of human orexin-A: regulator of appetite and wakefulness., Kim HY, Hong E, Kim JI, Lee W, J Biochem Mol Biol. 2004 Sep 30;37(5):565-73. PMID:15479620

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